|
【结 构 式】 
|
【分子编号】61220 【品名】benzyl (1R)-4-{[(benzyloxy)carbonyl]amino}-1-{2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl}butylcarbamate 【CA登记号】 |
【 分 子 式 】C26H29N3O8 【 分 子 量 】511.53168 【元素组成】C 61.05% H 5.71% N 8.21% O 25.02% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Protection of (R)-beta-lysine (I) by means of benzyl S-(4,6-dimethylpyrimidin-2-yl)thiol carbonate (II) affords the bis-(benzyloxycarbonyl) derivative (III). After activation of the carboxyl group of (III) as the corresponding succinimidyl ester (IV), its coupling with 1-methylhydrazinoacetic acid (V) furnishes hydrazide (VI). The benzyloxycarbonyl protecting groups of (VI) are finally removed by catalytic hydrogenolysis to provide the title compound.
| 【1】 Umezawa, H.; Kondo, S. (Microbial Chemistry Research Foundation); delta-Substd. negamycin derivs. and syntheses. US 4065495 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 61218 | (3R)-3,6-diaminohexanoic acid | C6H14N2O2 | 详情 | 详情 | |
| (II) | 32266 | O-benzyl S-(4,6-dimethyl-2-pyrimidinyl) carbonothioate; benzyl S-4,6-dimethylpyrimidin-2-ylthiolcarbonate | C14H14N2O2S | 详情 | 详情 | |
| (III) | 61219 | (3R)-3,6-bis{[(benzyloxy)carbonyl]amino}hexanoic acid | C22H26N2O6 | 详情 | 详情 | |
| (IV) | 61220 | benzyl (1R)-4-{[(benzyloxy)carbonyl]amino}-1-{2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl}butylcarbamate | C26H29N3O8 | 详情 | 详情 | |
| (V) | 61221 | 2-(1-methylhydrazino)acetic acid | C3H8N2O2 | 详情 | 详情 | |
| (VI) | 61222 | 2-[2-((3R)-3,6-bis{[(benzyloxy)carbonyl]amino}hexanoyl)-1-methylhydrazino]acetic acid | C25H32N4O7 | 详情 | 详情 |
Extended Information