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【结 构 式】

【分子编号】60986

【品名】1-methoxy-N-phenyl-2-indanamine; N-(1-methoxy-2,3-dihydro-1H-inden-2-yl)-N-phenylamine

【CA登记号】

【 分 子 式 】C16H17NO

【 分 子 量 】239.31712

【元素组成】C 80.3% H 7.16% N 5.85% O 6.69%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

This compound can be prepared by three different related ways: 1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1). 2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV), which is then condensed with diethylamine by means of NaI in refluxing ethanol (2). 3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).

1 (A. Christiaens SA); .
2 Vanhoof, P.; De Ridder, R. (A. Christiaens SA); CA 1068239; CH 617663; DD 123598; ZA 7607468 .
3 Blancafort, P.; Serradell, M.N.; Castaner, J.; Thorpe, P.J..; Moxaprindine. Drugs Fut 1981, 6, 6, 354.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60986 1-methoxy-N-phenyl-2-indanamine; N-(1-methoxy-2,3-dihydro-1H-inden-2-yl)-N-phenylamine C16H17NO 详情 详情
(II) 60989 3-bromo-N,N-diethyl-1-propanamine; N-(3-bromopropyl)-N,N-diethylamine C7H16BrN 详情 详情
(III) 10358 1-Bromo-3-chloropropane 109-70-6 C3H6BrCl 详情 详情
(IV) 60987 N-(3-chloropropyl)-1-methoxy-N-phenyl-2-indanamine; N-(3-chloropropyl)-N-(1-methoxy-2,3-dihydro-1H-inden-2-yl)-N-phenylamine C19H22ClNO 详情 详情
(V) 60988 1-methoxy-2,3-dihydro-1H-inden-2-yl methanesulfonate C11H14O4S 详情 详情
(VI) 60990 N-(3-anilinopropyl)-N,N-diethylamine; N~1~,N~1~-diethyl-N~3~-phenyl-1,3-propanediamine C13H22N2 详情 详情
Extended Information