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【结 构 式】 
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【药物名称】Moxaprindine 【化学名称】N1,N1-Diethyl-N3-(1-methoxyindan-2-yl)-N3-phenylpropane-1,3-diamine 【CA登记号】53076-26-9 【 分 子 式 】C23H32N2O 【 分 子 量 】352.52429 |
【开发单位】 【药理作用】 |
合成路线1
This compound can be prepared by three different related ways: 1) By condensation of 1-methoxy-2-aminoindane (I) with 3-bromopropyl diethylamine (II) by means of sodium amide in refluxing toluene (1). 2) The reaction of (I) with 1-chloro-3-bromopropane (III) by heating at 100 C gives the corresponding N-(3-chloropropyl) derivative (IV), which is then condensed with diethylamine by means of NaI in refluxing ethanol (2). 3) By condensation of 1-methoxy-2-indanyl methanesulfonate (V) with N-(diethylaminopropyl)aniline (VI) in refluxing ethanol (2).
| 【1】 (A. Christiaens SA); . |
| 【2】 Vanhoof, P.; De Ridder, R. (A. Christiaens SA); CA 1068239; CH 617663; DD 123598; ZA 7607468 . |
| 【3】 Blancafort, P.; Serradell, M.N.; Castaner, J.; Thorpe, P.J..; Moxaprindine. Drugs Fut 1981, 6, 6, 354. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 60986 | 1-methoxy-N-phenyl-2-indanamine; N-(1-methoxy-2,3-dihydro-1H-inden-2-yl)-N-phenylamine | C16H17NO | 详情 | 详情 | |
| (II) | 60989 | 3-bromo-N,N-diethyl-1-propanamine; N-(3-bromopropyl)-N,N-diethylamine | C7H16BrN | 详情 | 详情 | |
| (III) | 10358 | 1-Bromo-3-chloropropane | 109-70-6 | C3H6BrCl | 详情 | 详情 |
| (IV) | 60987 | N-(3-chloropropyl)-1-methoxy-N-phenyl-2-indanamine; N-(3-chloropropyl)-N-(1-methoxy-2,3-dihydro-1H-inden-2-yl)-N-phenylamine | C19H22ClNO | 详情 | 详情 | |
| (V) | 60988 | 1-methoxy-2,3-dihydro-1H-inden-2-yl methanesulfonate | C11H14O4S | 详情 | 详情 | |
| (VI) | 60990 | N-(3-anilinopropyl)-N,N-diethylamine; N~1~,N~1~-diethyl-N~3~-phenyl-1,3-propanediamine | C13H22N2 | 详情 | 详情 |
Extended Information