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【结 构 式】

【分子编号】60952

【品名】1-(4-methoxyphenyl)-2-pyrrolidinone

【CA登记号】

【 分 子 式 】C11H13NO2

【 分 子 量 】191.22976

【元素组成】C 69.09% H 6.85% N 7.32% O 16.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

(4-Methoxyphenyl)-2-pyrrolidone (I) is reacted with methanol / acid to the compound (II), which can be acetylated with 4-chlorobenzoyl chloride (III) in pyridine to yield (IV) and finally hydrolyzed to clanobutin

1 Unterhalt, B.; Clanobutin. Drugs Fut 1979, 4, 6, 411.
2 Klemm, K.; et al.; Synthese und physikalish-chemische Eigenschaften von Clanobutin. Arzneim-Forsch/Drug Res 1979, 29, 1, 1.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60952 1-(4-methoxyphenyl)-2-pyrrolidinone C11H13NO2 详情 详情
(II) 60953 methyl 4-(4-methoxyanilino)butanoate C12H17NO3 详情 详情
(III) 10295 p-Chlorobenzoyl chloride; 4-Chlorobenzoyl chloride 122-01-0 C7H4Cl2O 详情 详情
(IV) 60954 methyl 4-[(4-chlorobenzoyl)-4-methoxyanilino]butanoate C19H20ClNO4 详情 详情
Extended Information