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【结 构 式】

【分子编号】60924

【品名】5-chloro-N,2-dihydroxybenzamide

【CA登记号】

【 分 子 式 】C7H6ClNO3

【 分 子 量 】187.58228

【元素组成】C 44.82% H 3.22% Cl 18.9% N 7.47% O 25.59%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

By cyclization of 5-chlorosalicylhidroxamic acid (I) with 3-methylacrolein (II) by means of HCl in ethanol or acetic acid that gives 6-chloro-2-(2-chloropropyl)-2,3-dihydro-3-hydroxy-4H-1,3-benzoxazin-4-one (III), which is finally cyclized again with aqueous NaOH, or sodium methoxide in methanol

1 Castaner, J.; Arrigoni, Martelli, E.; Meseclazone. Drugs Fut 1977, 2, 6, 380.
2 Reisner, D.B.; et al. (Carter-Wallace, Inc.); DE 2010418; US 3598814 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60924 5-chloro-N,2-dihydroxybenzamide C7H6ClNO3 详情 详情
(II) 22517 (E)-2-butenal 4170-30-3 C4H6O 详情 详情
(III) 60925 6-chloro-2-(2-chloropropyl)-3-hydroxy-2,3-dihydro-4H-1,3-benzoxazin-4-one C11H11Cl2NO3 详情 详情
Extended Information