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【结 构 式】 
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【药物名称】Meseclazone, W-2395 【化学名称】7-Chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo[3,2-b][1,3]benzoxazin-9-one 【CA登记号】29053-27-8 【 分 子 式 】C11H10ClNO3 【 分 子 量 】239.66025 |
【开发单位】 【药理作用】 |
合成路线1
By cyclization of 5-chlorosalicylhidroxamic acid (I) with 3-methylacrolein (II) by means of HCl in ethanol or acetic acid that gives 6-chloro-2-(2-chloropropyl)-2,3-dihydro-3-hydroxy-4H-1,3-benzoxazin-4-one (III), which is finally cyclized again with aqueous NaOH, or sodium methoxide in methanol
| 【1】 Castaner, J.; Arrigoni, Martelli, E.; Meseclazone. Drugs Fut 1977, 2, 6, 380. |
| 【2】 Reisner, D.B.; et al. (Carter-Wallace, Inc.); DE 2010418; US 3598814 . |
Extended Information