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【结 构 式】

【分子编号】60864

【品名】4-[hydroxy(1-methyl-1H-imidazol-2-yl)methyl]benzonitrile

【CA登记号】

【 分 子 式 】C12H11N3O

【 分 子 量 】213.23896

【元素组成】C 67.59% H 5.2% N 19.71% O 7.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

Lithiation of 1-methylimidazole (VII), followed by quenching with triethylchlorosilane provides the 2-silyl imidazole (VIII). After metalation of (VIII) with tert-butyllithium, condensation with 4-cyanobenzaldehyde (IX) gives rise to the carbinol (X). Finally, coupling between alcohols (VI) and (X) in the presence of p-toluenesulfonic acid in refluxing toluene leads to the desired ether adduct.

1 Hasvold, L.A.; et al.; Design and synthesis of pyridone farnesyltransferase inhibitors. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 126.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VI) 60862 5-(3-chlorophenyl)-6-(hydroxymethyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile C13H9ClN2O2 详情 详情
(VII) 38630 1-methyl-1H-imidazole 616-47-7 C4H6N2 详情 详情
(VIII) 60863 1-methyl-2-(tripropylsilyl)-1H-imidazole C13H26N2Si 详情 详情
(IX) 17552 4-formylbenzonitrile; 4-Cyanobenzaldehyde 105-07-7 C8H5NO 详情 详情
(X) 60864 4-[hydroxy(1-methyl-1H-imidazol-2-yl)methyl]benzonitrile C12H11N3O 详情 详情
Extended Information