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【结 构 式】 
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【分子编号】60864 【品名】4-[hydroxy(1-methyl-1H-imidazol-2-yl)methyl]benzonitrile 【CA登记号】 |
【 分 子 式 】C12H11N3O 【 分 子 量 】213.23896 【元素组成】C 67.59% H 5.2% N 19.71% O 7.5% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)Lithiation of 1-methylimidazole (VII), followed by quenching with triethylchlorosilane provides the 2-silyl imidazole (VIII). After metalation of (VIII) with tert-butyllithium, condensation with 4-cyanobenzaldehyde (IX) gives rise to the carbinol (X). Finally, coupling between alcohols (VI) and (X) in the presence of p-toluenesulfonic acid in refluxing toluene leads to the desired ether adduct.
| 【1】 Hasvold, L.A.; et al.; Design and synthesis of pyridone farnesyltransferase inhibitors. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 126. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 60862 | 5-(3-chlorophenyl)-6-(hydroxymethyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile | C13H9ClN2O2 | 详情 | 详情 | |
| (VII) | 38630 | 1-methyl-1H-imidazole | 616-47-7 | C4H6N2 | 详情 | 详情 |
| (VIII) | 60863 | 1-methyl-2-(tripropylsilyl)-1H-imidazole | C13H26N2Si | 详情 | 详情 | |
| (IX) | 17552 | 4-formylbenzonitrile; 4-Cyanobenzaldehyde | 105-07-7 | C8H5NO | 详情 | 详情 |
| (X) | 60864 | 4-[hydroxy(1-methyl-1H-imidazol-2-yl)methyl]benzonitrile | C12H11N3O | 详情 | 详情 |
Extended Information