1-methyl-2-(tripropylsilyl)-1H-imidazole -Drug Synthesis Database

【结构式】

【分子编号】60863

【品名】1-methyl-2-(tripropylsilyl)-1H-imidazole

【CA登记号】

【分子式】C₁₃H₂₆N₂Si

【分子量】238.44842

【元素组成】C 65.48% H 10.99% N 11.75% Si 11.78%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

Lithiation of 1-methylimidazole (VII), followed by quenching with triethylchlorosilane provides the 2-silyl imidazole (VIII). After metalation of (VIII) with tert-butyllithium, condensation with 4-cyanobenzaldehyde (IX) gives rise to the carbinol (X). Finally, coupling between alcohols (VI) and (X) in the presence of p-toluenesulfonic acid in refluxing toluene leads to the desired ether adduct.

参考文献中间体

合成目标

【1】 Hasvold, L.A.; et al.; Design and synthesis of pyridone farnesyltransferase inhibitors. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 126.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	60862	5-(3-chlorophenyl)-6-(hydroxymethyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile		C₁₃H₉ClN₂O₂	详情	详情
(VII)	38630	1-methyl-1H-imidazole	616-47-7	C₄H₆N₂	详情	详情
(VIII)	60863	1-methyl-2-(tripropylsilyl)-1H-imidazole		C₁₃H₂₆N₂Si	详情	详情
(IX)	17552	4-formylbenzonitrile; 4-Cyanobenzaldehyde	105-07-7	C₈H₅NO	详情	详情
(X)	60864	4-[hydroxy(1-methyl-1H-imidazol-2-yl)methyl]benzonitrile		C₁₂H₁₁N₃O	详情	详情

Extended Information