• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】60860

【品名】5-(3-chlorophenyl)-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile

【CA登记号】

【 分 子 式 】C13H9ClN2O

【 分 子 量 】244.68004

【元素组成】C 63.82% H 3.71% Cl 14.49% N 11.45% O 6.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Bromination of 3-cyano-6-methyl-2-pyridone (I) by means of N bromosuccinimide (NBS) in 1,2-dichloroethane affords the 5-bromopyridone (II). Subsequent Suzuki coupling of (II) with 3-chlorophenylboronic acid (III) yields the 5-phenylpyridone (IV). Radical bromination of (IV) with NBS and AIBN produces the bromomethyl derivative (V). This is then converted to alcohol (VI) upon refluxing in aqueous dioxane in the presence of celite

1 Hasvold, L.A.; et al.; Design and synthesis of pyridone farnesyltransferase inhibitors. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 126.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 27560 6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 4241-27-4 C7H6N2O 详情 详情
(II) 60859 5-bromo-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile C7H5BrN2O 详情 详情
(III) 39759 3-chlorophenylboronic acid 63503-60-6 C6H6BClO2 详情 详情
(IV) 60860 5-(3-chlorophenyl)-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile C13H9ClN2O 详情 详情
(V) 60861 6-(bromomethyl)-5-(3-chlorophenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile C13H8BrClN2O 详情 详情
(VI) 60862 5-(3-chlorophenyl)-6-(hydroxymethyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile C13H9ClN2O2 详情 详情
Extended Information