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【结 构 式】 
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【分子编号】60699 【品名】(2R)-3-(tert-butoxycarbonyl)-2-isobutyl-6-phenylhexanoic acid 【CA登记号】 |
【 分 子 式 】C21H32O4 【 分 子 量 】348.48268 【元素组成】C 72.38% H 9.26% O 18.36% |
合成路线1
该中间体在本合成路线中的序号：(VII)(R)-2-Bromo-4-methylpentanoic acid (I) was protected as the benzyl ester (II) and subsequently condensed with benzyl tert-butyl malonate (III) in the presence of potassium tert-butoxide to furnish the triester (IV) as an epimeric mixture. Alkylation of (IV) with cinnamyl bromide (V) produced adduct (VI). The key intermediate (VII) was then obtained by catalytic hydrogenation of the benzyl esters and olefin double bond of (VI), followed by thermal malonate decarboxylation.
| 【1】 Fujisawa, T.; Odake, S.; Morita, Y.; Hongo, T.; Ito, H.; Yasuda, J.; Suda, E.; Igeta, K.; Morikawa, T. (Fuji Yakuhin Kogyo Co., Ltd.); Highly water-soluble metalloproteinase inhibitor. EP 0832875; WO 9633968 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26058 | (2S)-2-bromo-4-methylpentanoic acid | C6H11BrO2 | 详情 | 详情 | |
| (II) | 60695 | benzyl (2R)-2-bromo-4-methylpentanoate | C13H17BrO2 | 详情 | 详情 | |
| (III) | 60696 | 1-benzyl 3-(tert-butyl) malonate | C14H18O4 | 详情 | 详情 | |
| (IV) | 60697 | 1,2-dibenzyl 1-(tert-butyl) (2R)-4-methyl-1,1,2-pentanetricarboxylate | C27H34O6 | 详情 | 详情 | |
| (V) | 21131 | 1-[(E)-3-bromo-1-propenyl]benzene | 4392-24-9 | C9H9Br | 详情 | 详情 |
| (VI) | 60698 | 4,5-dibenzyl 4-(tert-butyl) (E,5R)-7-methyl-1-phenyl-1-octene-4,4,5-tricarboxylate | C36H42O6 | 详情 | 详情 | |
| (VII) | 60699 | (2R)-3-(tert-butoxycarbonyl)-2-isobutyl-6-phenylhexanoic acid | C21H32O4 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VII)N-Boc-L-4'-Aminophenylalanine-N-methylamide (VIII) was converted to the guanidine derivative (X) by reaction with pyrazole-N,N'-bis(benzyloxycarbonyl)carboxamidine (IX). After acidic Boc group cleavage in (IX), the resultant amino amide (XI) was coupled with the carboxylic acid (VII) to produce a diastereomeric mixture of amides, which were separated by column chromatography. The desired isomer (XII) was then treated with 95% aqueous trifluoroacetic acid to remove the tert-butyl ester group, yielding acid (XIII). Coupling of (XIII) with O-benzyl hydroxylamine furnished the O-benzyl hydroxamate (XIV). Finally, the benzyl and benzyloxycarbonyl protecting groups of (XIV) were removed by catalytic hydrogenation over Pd/C to afford the title compound.
| 【1】 Fujisawa, T.; Odake, S.; Morita, Y.; Hongo, T.; Ito, H.; Yasuda, J.; Suda, E.; Igeta, K.; Morikawa, T. (Fuji Yakuhin Kogyo Co., Ltd.); Highly water-soluble metalloproteinase inhibitor. EP 0832875; WO 9633968 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 60699 | (2R)-3-(tert-butoxycarbonyl)-2-isobutyl-6-phenylhexanoic acid | C21H32O4 | 详情 | 详情 | |
| (VIII) | 60700 | tert-butyl (1S)-1-(4-aminobenzyl)-2-(methylamino)-2-oxoethylcarbamate | C15H23N3O3 | 详情 | 详情 | |
| (IX) | 60787 | C6H10N4 | 详情 | 详情 | ||
| (X) | 60788 | benzyl (Z)-{[(benzyloxy)carbonyl]amino}{4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-(methylamino)-3-oxopropyl]anilino}methylidenecarbamate | C32H37N5O7 | 详情 | 详情 | |
| (XI) | 60789 | benzyl (Z)-{4-[(2S)-2-amino-3-(methylamino)-3-oxopropyl]anilino}{[(benzyloxy)carbonyl]amino}methylidenecarbamate | C27H29N5O5 | 详情 | 详情 | |
| (XII) | 60790 | tert-butyl (2S,3R)-3-({[(1S)-1-{4-[({[(benzyloxy)carbonyl]amino}{[(benzyloxy)carbonyl]imino}methyl)amino]benzyl}-2-(methylamino)-2-oxoethyl]amino}carbonyl)-5-methyl-2-(3-phenylpropyl)hexanoate | C48H59N5O8 | 详情 | 详情 | |
| (XIII) | 60791 | (2S,3R)-3-({[(1S)-1-{4-[({[(benzyloxy)carbonyl]amino}{[(benzyloxy)carbonyl]imino}methyl)amino]benzyl}-2-(methylamino)-2-oxoethyl]amino}carbonyl)-5-methyl-2-(3-phenylpropyl)hexanoic acid | C44H51N5O8 | 详情 | 详情 | |
| (XIV) | 60792 | benzyl (Z)-{4-[(2S)-2-[((2R,3S)-3-{[(benzyloxy)amino]carbonyl}-2-isobutyl-6-phenylhexanoyl)amino]-3-(methylamino)-3-oxopropyl]anilino}{[(benzyloxy)carbonyl]amino}methylidenecarbamate | C51H58N6O8 | 详情 | 详情 |