• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】60695

【品名】benzyl (2R)-2-bromo-4-methylpentanoate

【CA登记号】

【 分 子 式 】C13H17BrO2

【 分 子 量 】285.18078

【元素组成】C 54.75% H 6.01% Br 28.02% O 11.22%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

(R)-2-Bromo-4-methylpentanoic acid (I) was protected as the benzyl ester (II) and subsequently condensed with benzyl tert-butyl malonate (III) in the presence of potassium tert-butoxide to furnish the triester (IV) as an epimeric mixture. Alkylation of (IV) with cinnamyl bromide (V) produced adduct (VI). The key intermediate (VII) was then obtained by catalytic hydrogenation of the benzyl esters and olefin double bond of (VI), followed by thermal malonate decarboxylation.

1 Fujisawa, T.; Odake, S.; Morita, Y.; Hongo, T.; Ito, H.; Yasuda, J.; Suda, E.; Igeta, K.; Morikawa, T. (Fuji Yakuhin Kogyo Co., Ltd.); Highly water-soluble metalloproteinase inhibitor. EP 0832875; WO 9633968 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 26058 (2S)-2-bromo-4-methylpentanoic acid C6H11BrO2 详情 详情
(II) 60695 benzyl (2R)-2-bromo-4-methylpentanoate C13H17BrO2 详情 详情
(III) 60696 1-benzyl 3-(tert-butyl) malonate C14H18O4 详情 详情
(IV) 60697 1,2-dibenzyl 1-(tert-butyl) (2R)-4-methyl-1,1,2-pentanetricarboxylate C27H34O6 详情 详情
(V) 21131 1-[(E)-3-bromo-1-propenyl]benzene 4392-24-9 C9H9Br 详情 详情
(VI) 60698 4,5-dibenzyl 4-(tert-butyl) (E,5R)-7-methyl-1-phenyl-1-octene-4,4,5-tricarboxylate C36H42O6 详情 详情
(VII) 60699 (2R)-3-(tert-butoxycarbonyl)-2-isobutyl-6-phenylhexanoic acid C21H32O4 详情 详情
Extended Information