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【结 构 式】 
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【分子编号】60633 【品名】3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate 【CA登记号】 |
【 分 子 式 】C27H44N4O5 【 分 子 量 】504.67032 【元素组成】C 64.26% H 8.79% N 11.1% O 15.85% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of N-benzoyl-N',N'-di-n-propyl-DL-isoglutamine (I) with N-3-chloropropyl-N'-2-hydroxyethylpiperazine (II) by means of sodium methoxide in DMSO at 105 C gives N-[3-(N-benzoyl-N',N'-di-n-propyl-DL-isoglutaminyl)oxypropyl]-N'-(2-hydroxyethyl)piperazine (III), which is then condensed with 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid (IV) by means of dicyclohexylcarbodiimide and NaHCO3 in ethyl acetate, and treated finally with maleic acid (V)
| 【1】 Blancafort, P.; Serradell, M.N.; Castaner, J.; de Angelis, L.; Proglumetacin maleate. Drugs Fut 1980, 5, 3, 142. |
| 【2】 Makovec, F.; et al. (Rotta Research Laboratorium SpA); BE 830880; CA 1053663; DE 2535799; FR 2281755; GB 1467568; JP 7643773; JP 7643774; JP 7916511; JP 7916512; NL 7509091; SA 7509091; US 3985878 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 60631 | 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid | C18H26N2O4 | 详情 | 详情 | |
| (II) | 60632 | 2-[4-(3-chloropropyl)-1-piperazinyl]-1-ethanol | C9H19ClN2O | 详情 | 详情 | |
| (III) | 60633 | 3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate | C27H44N4O5 | 详情 | 详情 | |
| (IV) | 22930 | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid | C19H16ClNO4 | 详情 | 详情 | |
| (V) | 37495 | Maleic acid; (Z)-2-Butenedioic acid | 110-16-7 | C4H4O4 | 详情 | 详情 |
Extended Information