• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】60631

【品名】4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid

【CA登记号】

【 分 子 式 】C18H26N2O4

【 分 子 量 】334.41552

【元素组成】C 64.65% H 7.84% N 8.38% O 19.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The reaction of N-benzoyl-N',N'-di-n-propyl-DL-isoglutamine (I) with N-3-chloropropyl-N'-2-hydroxyethylpiperazine (II) by means of sodium methoxide in DMSO at 105 C gives N-[3-(N-benzoyl-N',N'-di-n-propyl-DL-isoglutaminyl)oxypropyl]-N'-(2-hydroxyethyl)piperazine (III), which is then condensed with 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid (IV) by means of dicyclohexylcarbodiimide and NaHCO3 in ethyl acetate, and treated finally with maleic acid (V)

1 Blancafort, P.; Serradell, M.N.; Castaner, J.; de Angelis, L.; Proglumetacin maleate. Drugs Fut 1980, 5, 3, 142.
2 Makovec, F.; et al. (Rotta Research Laboratorium SpA); BE 830880; CA 1053663; DE 2535799; FR 2281755; GB 1467568; JP 7643773; JP 7643774; JP 7916511; JP 7916512; NL 7509091; SA 7509091; US 3985878 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60631 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid C18H26N2O4 详情 详情
(II) 60632 2-[4-(3-chloropropyl)-1-piperazinyl]-1-ethanol C9H19ClN2O 详情 详情
(III) 60633 3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate C27H44N4O5 详情 详情
(IV) 22930 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid C19H16ClNO4 详情 详情
(V) 37495 Maleic acid; (Z)-2-Butenedioic acid 110-16-7 C4H4O4 详情 详情
Extended Information