{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol -Drug Synthesis Database

【结构式】

【分子编号】60073

【品名】{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol

【CA登记号】

【分子式】C₁₈H₁₇NO₃

【分子量】295.33792

【元素组成】C 73.2% H 5.8% N 4.74% O 16.25%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Reduction of 4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (I) with NaBH4 affords alcohol (II). Subsequent chlorination of (II) employing thionyl chloride in toluene leads to the benzyl chloride (III)

参考文献中间体

合成目标

【1】 Imoto, H.; Imamiya, E.; Momose, Y.; Sugiyama, Y.; Kimura, H.; Sohda, T.; Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives. Chem Pharm Bull 2002, 50, 10, 1349.
【2】 Kimura, H.; Momose, Y.; Odaka, H.; Sakamoto, J.; Imoto, H. (Takeda Chemical Industries, Ltd.); Oxyiminoalkanoic acid derivs. with hypoglycemic and hypolipidemic activity. EP 1077957; JP 2000034266; JP 2000198772; US 6251926; US 6495581; WO 9958510 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	60072	4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzaldehyde	C₁₈H₁₅NO₃	详情	详情
(II)	60073	{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol	C₁₈H₁₇NO₃	详情	详情
(III)	60074	4-(chloromethyl)phenyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl ether; 4-{[4-(chloromethyl)phenoxy]methyl}-5-methyl-2-phenyl-1,3-oxazole	C₁₈H₁₆ClNO₂	详情	详情

Extended Information