【结 构 式】 |
【分子编号】60072 【品名】4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzaldehyde 【CA登记号】 |
【 分 子 式 】C18H15NO3 【 分 子 量 】293.32204 【元素组成】C 73.71% H 5.15% N 4.78% O 16.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)Reduction of 4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (I) with NaBH4 affords alcohol (II). Subsequent chlorination of (II) employing thionyl chloride in toluene leads to the benzyl chloride (III)
【1】 Imoto, H.; Imamiya, E.; Momose, Y.; Sugiyama, Y.; Kimura, H.; Sohda, T.; Studies on non-thiazolidinedione antidiabetic agents. 1. Discovery of novel oxyiminoacetic acid derivatives. Chem Pharm Bull 2002, 50, 10, 1349. |
【2】 Kimura, H.; Momose, Y.; Odaka, H.; Sakamoto, J.; Imoto, H. (Takeda Chemical Industries, Ltd.); Oxyiminoalkanoic acid derivs. with hypoglycemic and hypolipidemic activity. EP 1077957; JP 2000034266; JP 2000198772; US 6251926; US 6495581; WO 9958510 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 60072 | 4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzaldehyde | C18H15NO3 | 详情 | 详情 | |
(II) | 60073 | {4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol | C18H17NO3 | 详情 | 详情 | |
(III) | 60074 | 4-(chloromethyl)phenyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl ether; 4-{[4-(chloromethyl)phenoxy]methyl}-5-methyl-2-phenyl-1,3-oxazole | C18H16ClNO2 | 详情 | 详情 |
Extended Information