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【结 构 式】 
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【分子编号】59905 【品名】(1R,3aR,7aR)-1-{(1R)-1,5-dimethyl-5-[(triethylsilyl)oxy]hexyl}-7a-methyloctahydro-4H-inden-4-one 【CA登记号】 |
【 分 子 式 】C24H46O2Si 【 分 子 量 】394.71354 【元素组成】C 73.03% H 11.75% O 8.11% Si 7.12% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXXIII)Allyl alcohol (XXX) was converted to chloride (XXXI) by means of N-chlorosuccinimide and dimethylsulfide. Displacement of the chloride ion of (XXXI) with lithium diphenylphosphide, followed by H2O2 oxidation of the resulting phosphine gave the phosphine oxide (XXXII). This was subjected to a Wittig condensation with the functionalized indanone (XXXIII) to produce the triene adduct (XXXIV). Final desilylation of (XXXIV) to the title compound was effected by treatment with tetrabutylammonium fluoride in THF
| 【1】 Takahashi, T.; Shiono, M. (Kuraray Co., Ltd.); Cyclohexanetriol derivs.. EP 0503630 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXX) | 59876 | 2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]-1-ethanol | C60H74O5Si3 | 详情 | 详情 | |
| (XXXI) | 59877 | tert-butyl({(1R,2R,3R)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-5-[(Z)-2-chloroethylidene]-4-methylenecyclohexyl}oxy)diphenylsilane; (1R,2R,6R)-2,6-bis{[tert-butyl(diphenyl)silyl]oxy}-4-[(Z)-2-chloroethylidene]-3-methylenecyclohexyl 3-{[tert-butyl(diphenyl)silyl]oxy}propyl ether | C60H73ClO4Si3 | 详情 | 详情 | |
| (XXXII) | 59878 | 2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]ethyl(diphenyl)phosphine oxide; {2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]ethyl}(oxo)diphenylphosphorane | C72H83O5PSi3 | 详情 | 详情 | |
| (XXXIII) | 59905 | (1R,3aR,7aR)-1-{(1R)-1,5-dimethyl-5-[(triethylsilyl)oxy]hexyl}-7a-methyloctahydro-4H-inden-4-one | C24H46O2Si | 详情 | 详情 | |
| (XXXIV) | 59879 | C81H112O5Si4 | 详情 | 详情 |
Extended Information