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【结 构 式】

【分子编号】59879

【品名】 

【CA登记号】

【 分 子 式 】C81H112O5Si4

【 分 子 量 】1278.11928

【元素组成】C 76.12% H 8.83% O 6.26% Si 8.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXXIV)

Allyl alcohol (XXX) was converted to chloride (XXXI) by means of N-chlorosuccinimide and dimethylsulfide. Displacement of the chloride ion of (XXXI) with lithium diphenylphosphide, followed by H2O2 oxidation of the resulting phosphine gave the phosphine oxide (XXXII). This was subjected to a Wittig condensation with the functionalized indanone (XXXIII) to produce the triene adduct (XXXIV). Final desilylation of (XXXIV) to the title compound was effected by treatment with tetrabutylammonium fluoride in THF

1 Takahashi, T.; Shiono, M. (Kuraray Co., Ltd.); Cyclohexanetriol derivs.. EP 0503630 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XXX) 59876 2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]-1-ethanol C60H74O5Si3 详情 详情
(XXXI) 59877 tert-butyl({(1R,2R,3R)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-5-[(Z)-2-chloroethylidene]-4-methylenecyclohexyl}oxy)diphenylsilane; (1R,2R,6R)-2,6-bis{[tert-butyl(diphenyl)silyl]oxy}-4-[(Z)-2-chloroethylidene]-3-methylenecyclohexyl 3-{[tert-butyl(diphenyl)silyl]oxy}propyl ether C60H73ClO4Si3 详情 详情
(XXXII) 59878 2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]ethyl(diphenyl)phosphine oxide; {2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]ethyl}(oxo)diphenylphosphorane C72H83O5PSi3 详情 详情
(XXXIII) 59905 (1R,3aR,7aR)-1-{(1R)-1,5-dimethyl-5-[(triethylsilyl)oxy]hexyl}-7a-methyloctahydro-4H-inden-4-one C24H46O2Si 详情 详情
(XXXIV) 59879   C81H112O5Si4 详情 详情
Extended Information