【结 构 式】 |
【分子编号】59879 【品名】 【CA登记号】 |
【 分 子 式 】C81H112O5Si4 【 分 子 量 】1278.11928 【元素组成】C 76.12% H 8.83% O 6.26% Si 8.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XXXIV)Allyl alcohol (XXX) was converted to chloride (XXXI) by means of N-chlorosuccinimide and dimethylsulfide. Displacement of the chloride ion of (XXXI) with lithium diphenylphosphide, followed by H2O2 oxidation of the resulting phosphine gave the phosphine oxide (XXXII). This was subjected to a Wittig condensation with the functionalized indanone (XXXIII) to produce the triene adduct (XXXIV). Final desilylation of (XXXIV) to the title compound was effected by treatment with tetrabutylammonium fluoride in THF
【1】 Takahashi, T.; Shiono, M. (Kuraray Co., Ltd.); Cyclohexanetriol derivs.. EP 0503630 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XXX) | 59876 | 2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]-1-ethanol | C60H74O5Si3 | 详情 | 详情 | |
(XXXI) | 59877 | tert-butyl({(1R,2R,3R)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-5-[(Z)-2-chloroethylidene]-4-methylenecyclohexyl}oxy)diphenylsilane; (1R,2R,6R)-2,6-bis{[tert-butyl(diphenyl)silyl]oxy}-4-[(Z)-2-chloroethylidene]-3-methylenecyclohexyl 3-{[tert-butyl(diphenyl)silyl]oxy}propyl ether | C60H73ClO4Si3 | 详情 | 详情 | |
(XXXII) | 59878 | 2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]ethyl(diphenyl)phosphine oxide; {2-[(3R,4R,5R)-3,5-bis{[tert-butyl(diphenyl)silyl]oxy}-4-(3-{[tert-butyl(diphenyl)silyl]oxy}propoxy)-2-methylenecyclohexylidene]ethyl}(oxo)diphenylphosphorane | C72H83O5PSi3 | 详情 | 详情 | |
(XXXIII) | 59905 | (1R,3aR,7aR)-1-{(1R)-1,5-dimethyl-5-[(triethylsilyl)oxy]hexyl}-7a-methyloctahydro-4H-inden-4-one | C24H46O2Si | 详情 | 详情 | |
(XXXIV) | 59879 | C81H112O5Si4 | 详情 | 详情 |
Extended Information