(6aS,10aS)-9-(bromomethyl)-3-(1,1-dimethylheptyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol -Drug Synthesis Database

【结构式】

【分子编号】59612

【品名】(6aS,10aS)-9-(bromomethyl)-3-(1,1-dimethylheptyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

【CA登记号】

【分子式】C₂₅H₃₇BrO₂

【分子量】449.47158

【元素组成】C 66.81% H 8.3% Br 17.78% O 7.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Dexanabinol (I) was brominated using carbon tetrabromide in the presence of triphenylphosphine. The resultant allylic bromide (II) was then condensed with the lithium salt of imidazole (III) to produce the title compound.

参考文献中间体

合成目标

【1】 Fink, G.; Garzon, A. (Pharmos Corp.); Novel non-psychotropic cannabinoids. WO 0198289 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	59611	(6aS,10aS)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol		C₂₅H₃₈O₃	详情	详情
(II)	59612	(6aS,10aS)-9-(bromomethyl)-3-(1,1-dimethylheptyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol		C₂₅H₃₇BrO₂	详情	详情
(III)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情

Extended Information