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【结 构 式】 
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【药物名称】PRS-211095 【化学名称】(6aS,10aS)-3-(1,1-Dimethylheptyl)-9-(1H-imidazol-1-ylmethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-dibenzo[b,d]pyran-1-ol hydrochloride 【CA登记号】382137-87-3, 374110-39-1 (free base) 【 分 子 式 】C28H41ClN2O2 【 分 子 量 】473.10417 |
【开发单位】Pharmos (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Cyclooxygenase-2 Inhibitors, NMDA Antagonists |
合成路线1
Dexanabinol (I) was brominated using carbon tetrabromide in the presence of triphenylphosphine. The resultant allylic bromide (II) was then condensed with the lithium salt of imidazole (III) to produce the title compound.
| 【1】 Fink, G.; Garzon, A. (Pharmos Corp.); Novel non-psychotropic cannabinoids. WO 0198289 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 59611 | (6aS,10aS)-3-(1,1-dimethylheptyl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol | C25H38O3 | 详情 | 详情 | |
| (II) | 59612 | (6aS,10aS)-9-(bromomethyl)-3-(1,1-dimethylheptyl)-6,6-dimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol | C25H37BrO2 | 详情 | 详情 | |
| (III) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
Extended Information