【结 构 式】 |
【分子编号】59523 【品名】1-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazine 【CA登记号】 |
【 分 子 式 】C20H20F2N2 【 分 子 量 】326.3890864 【元素组成】C 73.6% H 6.18% F 11.64% N 8.58% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XVII)Condensation of the anti-bromo derivative (XII) with piperazine (XVI) in refluxing acetonitrile provides 1-[10,11-(difluoromethano)dibenzosuber-5-yl]piperazine as a mixture of syn- and anti-isomers (XVII), which is separated by crystallization. Finally, the desired anti-isomer (VIII) is condensed with 5-[2(R),3-epoxypropoxy]quinoline (IX) in hot ethanol.
【1】 Sorbera, L.A.; Castaner, J.; Silvestre, J.S.; Bayes, M.; Zosuquidar Trihydrochloride.. Drugs Fut 2003, 28, 2, 125-136. |
【2】 Barnett, C.J.; Wilson, T.M.; Astleford, B.A.; Kobierski, M.E. (Eli Lilly and Company); Process for preparing a 10,11-methanodibenzosuberane deriv.. WO 0075132 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VIII) | 56207 | 1-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazine | C20H20F2N2 | 详情 | 详情 | |
(IX) | 56211 | (2R)oxiranylmethyl 5-quinolinyl ether; 5-[(2R)oxiranylmethoxy]quinoline | C12H11NO2 | 详情 | 详情 | |
(XII) | 56208 | (1aR,10bS)-6-bromo-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cycloheptene | C16H11BrF2 | 详情 | 详情 | |
(XVI) | 10355 | Diethylenediamine; Piperazine | 110-85-0 | C4H10N2 | 详情 | 详情 |
(XVII) | 59523 | 1-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazine | C20H20F2N2 | 详情 | 详情 |
Extended Information