5-{acetyl[2-(acetyloxy)-3-methoxypropyl]amino}-2,4,6-triiodoisophthalic acid -Drug Synthesis Database

【结构式】

【分子编号】59319

【品名】5-{acetyl[2-(acetyloxy)-3-methoxypropyl]amino}-2,4,6-triiodoisophthalic acid

【CA登记号】

【分子式】C₁₆H₁₆I₃NO₈

【分子量】731.01839

【元素组成】C 26.29% H 2.21% I 52.08% N 1.92% O 17.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Alternatively, 5-acetamido-2,4,6-triiodoisophthalic acid (I) is alkylated with 1-chloro-3-methoxy-2-propanol (II) to produce (III). After protection of the alcoholic hydroxyl group as the acetate ester (IV), the carboxyl groups are activated as the corresponding acid chloride (V) with SOCl2. Coupling of (V) with 3-amino-1,2-propanediol (VI) then produces the title amide.

参考文献中间体

合成目标

【1】 Skjoeld, W.; Berg, A.; Preparative liquid chromatography in the field of X-ray contrast agents. J Chromatogr 1986, 366, 299.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	59317	5-(acetylamino)-2,4,6-triiodoisophthalic acid		C₁₀H₆I₃NO₅	详情	详情
(II)	34214	1-chloro-3-methoxy-2-propanol	4151-97-7	C₄H₉ClO₂	详情	详情
(III)	59318	5-[acetyl(2-hydroxy-3-methoxypropyl)amino]-2,4,6-triiodoisophthalic acid		C₁₄H₁₄I₃NO₇	详情	详情
(IV)	59319	5-{acetyl[2-(acetyloxy)-3-methoxypropyl]amino}-2,4,6-triiodoisophthalic acid		C₁₆H₁₆I₃NO₈	详情	详情
(V)	59320	2-[acetyl-3,5-bis(chlorocarbonyl)-2,4,6-triiodoanilino]-1-(methoxymethyl)ethyl acetate		C₁₆H₁₄Cl₂I₃NO₆	详情	详情
(VI)	12979	3-Amino-1,2-propanediol；3-aminopropane-1,2-diol	616-30-8	C₃H₉NO₂	详情	详情

Extended Information