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【结 构 式】 
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【分子编号】59318 【品名】5-[acetyl(2-hydroxy-3-methoxypropyl)amino]-2,4,6-triiodoisophthalic acid 【CA登记号】 |
【 分 子 式 】C14H14I3NO7 【 分 子 量 】688.98111 【元素组成】C 24.41% H 2.05% I 55.26% N 2.03% O 16.26% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Alternatively, 5-acetamido-2,4,6-triiodoisophthalic acid (I) is alkylated with 1-chloro-3-methoxy-2-propanol (II) to produce (III). After protection of the alcoholic hydroxyl group as the acetate ester (IV), the carboxyl groups are activated as the corresponding acid chloride (V) with SOCl2. Coupling of (V) with 3-amino-1,2-propanediol (VI) then produces the title amide.
| 【1】 Skjoeld, W.; Berg, A.; Preparative liquid chromatography in the field of X-ray contrast agents. J Chromatogr 1986, 366, 299. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 59317 | 5-(acetylamino)-2,4,6-triiodoisophthalic acid | C10H6I3NO5 | 详情 | 详情 | |
| (II) | 34214 | 1-chloro-3-methoxy-2-propanol | 4151-97-7 | C4H9ClO2 | 详情 | 详情 |
| (III) | 59318 | 5-[acetyl(2-hydroxy-3-methoxypropyl)amino]-2,4,6-triiodoisophthalic acid | C14H14I3NO7 | 详情 | 详情 | |
| (IV) | 59319 | 5-{acetyl[2-(acetyloxy)-3-methoxypropyl]amino}-2,4,6-triiodoisophthalic acid | C16H16I3NO8 | 详情 | 详情 | |
| (V) | 59320 | 2-[acetyl-3,5-bis(chlorocarbonyl)-2,4,6-triiodoanilino]-1-(methoxymethyl)ethyl acetate | C16H14Cl2I3NO6 | 详情 | 详情 | |
| (VI) | 12979 | 3-Amino-1,2-propanediol；3-aminopropane-1,2-diol | 616-30-8 | C3H9NO2 | 详情 | 详情 |
Extended Information