7-[(2-(2-amino-1,3-thiazol-4-yl)-2-{[(triphenylmethyl)oxy]imino}acetyl)amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】64883

【品名】7-[(2-(2-amino-1,3-thiazol-4-yl)-2-{[(triphenylmethyl)oxy]imino}acetyl)amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

【CA登记号】

【分子式】C₃₃H₂₇N₅O₅S₂

【分子量】637.74008

【元素组成】C 62.15% H 4.27% N 10.98% O 12.54% S 10.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of 2-(2-aminothiazol-4-yl)-2(Z)-(trityoloxyimino)thioacetic acid 2-benzothiazolyl ester (I) with 7-amino-3-vinyl-3-cephem-4-carboxylic acid (II) by means of tributylamine in DMA gives the corresponding amide (III), which is deprotected by means of HCl and formic acid to provide cefdinir.

参考文献中间体

合成目标

【1】 Singh, S.K.; Kumar, Y.; Prasad, M.; Prasad, A.; Kumar, N.P. (Ranbaxy Laboratories Ltd.); Process for the preparation of cefdinir. WO 0391261 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	64881	S-(1,3-benzothiazol-2-yl) 2-(2-amino-1,3-thiazol-4-yl)-2-{[(triphenylmethyl)oxy]imino}ethanethioate		C₃₁H₂₂N₄O₂S₃	详情	详情
(II)	64882	(6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid	79349-82-9	C₉H₁₀N₂O₃S	详情	详情
(III)	64883	7-[(2-(2-amino-1,3-thiazol-4-yl)-2-{[(triphenylmethyl)oxy]imino}acetyl)amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid		C₃₃H₂₇N₅O₅S₂	详情	详情

Extended Information