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【结 构 式】 
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【分子编号】62786 【品名】(2R,3R,4S)-4-amino-3-hydroxy-N-((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanamide 【CA登记号】 |
【 分 子 式 】C34H46N4O8 【 分 子 量 】638.7614 【元素组成】C 63.93% H 7.26% N 8.77% O 20.04% |
合成路线1
该中间体在本合成路线中的序号：(VII)Condensation of glycidate (I) with 3,4,5-trimethoxybenzyl amine (II) in hot EtOH affords the hydroxy amino ester (III). Subsequent ester hydrolysis in (III) employing LiOH yields carboxylic acid (IV). This is coupled to N-2-hydroxy-4-methoxybenzyl-L-valinamide (V) by means of TPTU to furnish (VI). Then, removal of the N-Boc protecting group of (VI) with HCl in dioxane provides amine (VII).
| 【1】 Lang, M.; Zimmermann, J.; Furet, P.; Garcia-Echeverria, C.; Imbach, P. (Novartis AG; Novartis Pharma GmbH); 2-Amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivs.. EP 1290012; US 2003166572; WO 0189282 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 62780 | C18H25NO5 | 详情 | 详情 | ||
| (II) | 62781 | 3,4,5-trimethoxybenzylamine; (3,4,5-trimethoxyphenyl)methanamine | C10H15NO3 | 详情 | 详情 | |
| (III) | 62782 | ethyl (2R,3S,4S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanoate | C28H40N2O8 | 详情 | 详情 | |
| (IV) | 62783 | (2R,3S,4S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanoic acid | C26H36N2O8 | 详情 | 详情 | |
| (V) | 62784 | (2S)-2-amino-N-(2-hydroxy-4-methoxybenzyl)-3-methylbutanamide | C13H20N2O3 | 详情 | 详情 | |
| (VI) | 62785 | tert-butyl (1S,2S,3R)-1-benzyl-2-hydroxy-4-[((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)amino]-4-oxo-3-[(3,4,5-trimethoxybenzyl)amino]butylcarbamate | C39H54N4O10 | 详情 | 详情 | |
| (VII) | 62786 | (2R,3R,4S)-4-amino-3-hydroxy-N-((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanamide | C34H46N4O8 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VII)Coupling of N-Boc-L-tert-leucine (VIII) to amine (VII) in the presence of TPTU gives rise to amide (IX). After acidic Boc group cleavage in (IX), the resultant amine (X) is finally acylated by 1-naphthylacetic acid (XI) to furnish the title compound.
| 【1】 Lang, M.; Zimmermann, J.; Furet, P.; Garcia-Echeverria, C.; Imbach, P. (Novartis AG; Novartis Pharma GmbH); 2-Amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivs.. EP 1290012; US 2003166572; WO 0189282 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 62786 | (2R,3R,4S)-4-amino-3-hydroxy-N-((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanamide | C34H46N4O8 | 详情 | 详情 | |
| (VIII) | 22251 | (2S)-2-[(tert-butoxycarbonyl)amino]-3,3-dimethylbutyric acid;2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoic acid;N-(tert-butoxycarbonyl)-3-methyl-L-valine | 62965-35-9 | C11H21NO4 | 详情 | 详情 |
| (IX) | 62787 | tert-butyl (1S)-1-[({(1S,2S,3R)-1-benzyl-2-hydroxy-4-[((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)amino]-4-oxo-3-[(3,4,5-trimethoxybenzyl)amino]butyl}amino)carbonyl]-2,2-dimethylpropylcarbamate | C45H65N5O11 | 详情 | 详情 | |
| (X) | 62788 | (2R,3S,4S)-4-{[(2S)-2-amino-3,3-dimethylbutanoyl]amino}-3-hydroxy-N-((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanamide | C40H57N5O9 | 详情 | 详情 | |
| (XI) | 51133 | Planofix; alpha-Naphthylacetic acid; 1-Naphthaleneacetic acid; 1-Naphthylacetic acid; alpha-Naphthaleneacetic acid; Naphthalene-1-acetic acid | 86-87-3 | C12H10O2 | 详情 | 详情 |