【结 构 式】 |
【分子编号】62781 【品名】3,4,5-trimethoxybenzylamine; (3,4,5-trimethoxyphenyl)methanamine 【CA登记号】 |
【 分 子 式 】C10H15NO3 【 分 子 量 】197.23404 【元素组成】C 60.9% H 7.67% N 7.1% O 24.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)Condensation of glycidate (I) with 3,4,5-trimethoxybenzyl amine (II) in hot EtOH affords the hydroxy amino ester (III). Subsequent ester hydrolysis in (III) employing LiOH yields carboxylic acid (IV). This is coupled to N-2-hydroxy-4-methoxybenzyl-L-valinamide (V) by means of TPTU to furnish (VI). Then, removal of the N-Boc protecting group of (VI) with HCl in dioxane provides amine (VII).
【1】 Lang, M.; Zimmermann, J.; Furet, P.; Garcia-Echeverria, C.; Imbach, P. (Novartis AG; Novartis Pharma GmbH); 2-Amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivs.. EP 1290012; US 2003166572; WO 0189282 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 62780 | C18H25NO5 | 详情 | 详情 | ||
(II) | 62781 | 3,4,5-trimethoxybenzylamine; (3,4,5-trimethoxyphenyl)methanamine | C10H15NO3 | 详情 | 详情 | |
(III) | 62782 | ethyl (2R,3S,4S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanoate | C28H40N2O8 | 详情 | 详情 | |
(IV) | 62783 | (2R,3S,4S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanoic acid | C26H36N2O8 | 详情 | 详情 | |
(V) | 62784 | (2S)-2-amino-N-(2-hydroxy-4-methoxybenzyl)-3-methylbutanamide | C13H20N2O3 | 详情 | 详情 | |
(VI) | 62785 | tert-butyl (1S,2S,3R)-1-benzyl-2-hydroxy-4-[((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)amino]-4-oxo-3-[(3,4,5-trimethoxybenzyl)amino]butylcarbamate | C39H54N4O10 | 详情 | 详情 | |
(VII) | 62786 | (2R,3R,4S)-4-amino-3-hydroxy-N-((1S)-1-{[(2-hydroxy-4-methoxybenzyl)amino]carbonyl}-2-methylpropyl)-5-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]pentanamide | C34H46N4O8 | 详情 | 详情 |
Extended Information