6-amino-5-(2,2-diethoxyethyl)-4(3H)-pyrimidinone -Drug Synthesis Database

【结构式】

【分子编号】60044

【品名】6-amino-5-(2,2-diethoxyethyl)-4(3H)-pyrimidinone

【CA登记号】

【分子式】C₁₀H₁₇N₃O₃

【分子量】227.2634

【元素组成】C 52.85% H 7.54% N 18.49% O 21.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation of 2-cyano-4,4-diethoxybutyric acid ethyl ester (I) with formamidine hydrochloride (II) in the presence of NaOEt provides the pyrimidine derivative (III). Subsequent hydrolysis of the diethyl acetal of (III) under acidic conditions leads to the pyrrolopyrimidinone (IV). This is converted to the 4-chloro derivative (V) upon treatment with POCl3. Then, oxidation of (V) by means of pyridinium bromide perbromide furnishes the dibromo pyrrolopyridinone (VI), which is further debrominated to (VII) employing zinc dust in AcOH

参考文献中间体

合成目标

【1】 Wei, C.C.; Tang, P.C.; McMahon, G.; Sun, L.; Hirth, K.P.; Liang, C.; Cui, J. (Sugen, Inc.); 4-Substd. 7-aza-indolin-2-ones and their use as protein kinase inhibitors. EP 1244672; WO 0146196 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14789	ethyl 2-cyano-4,4-diethoxybutanoate		C₁₁H₁₉NO₄	详情	详情
(II)	15369	Iminoformamide; Methanimidamide	463-52-5	CH₄N₂	详情	详情
(III)	60044	6-amino-5-(2,2-diethoxyethyl)-4(3H)-pyrimidinone		C₁₀H₁₇N₃O₃	详情	详情
(IV)	60045	3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one		C₆H₅N₃O	详情	详情
(V)	60046	4-chloro-7H-pyrrolo[2,3-d]pyrimidine；6-Chloro-7-deazapurine；4-chloropyrrolo[2,3-d]pyrimidine；4-Chloro-1H-pyrrolo[2,3-d]pyrimidine	3680-69-1	C₆H₄ClN₃	详情	详情
(VI)	60047	5,5-dibromo-4-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one		C₆H₂Br₂ClN₃O	详情	详情
(VII)	60048	4-chloro-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one		C₆H₄ClN₃O	详情	详情

Extended Information