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【结 构 式】

【分子编号】60035

【品名】1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-11-one

【CA登记号】

【 分 子 式 】C10H20N4O

【 分 子 量 】212.29516

【元素组成】C 56.58% H 9.5% N 26.39% O 7.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVI)

A different synthesis started from the previously reported tetraaza cyclopentaacenaphthylene (XV). Treatment of (XV) with a solution of piperazine at pH 6 gave rise to the bicyclic lactam (XVI). Alkylation of (XVI) with bromoacetic acid, followed by basic lactam hydrolysis furnished the tris(carboxymethyl) derivative (X), which was processed as in Scheme 3.

1 Argese, M.; Ripa, G. (Bracco SpA; Dibra SpA); 1,4,7,10-Tetraazabicyclo[8.2.2]tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles. EP 0998476; JP 2002511884; WO 9905145 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 23660 2-Bromoacetic acid 79-08-3 C2H3BrO2 详情 详情
(X) 60030 trisodium 2-[4,10-bis(2-oxido-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetate C14H23N4Na3O6 详情 详情
(XV) 60034 1,4,7,10-tetraazatricyclo[8.2.2.2~4,7~]hexadecane C12H24N4 详情 详情
(XVI) 60035 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-11-one C10H20N4O 详情 详情
(XVII) 60036 2-[7-(2-hydroxy-2-oxoethyl)-11-oxo-1,4,7,10-tetraazabicyclo[8.2.2]tetradec-4-yl]acetic acid C14H24N4O5 详情 详情
Extended Information