1,4,7,10-tetraazatricyclo[8.2.2.2~4,7~]hexadecane -Drug Synthesis Database

【结构式】

【分子编号】60034

【品名】1,4,7,10-tetraazatricyclo[8.2.2.2~4,7~]hexadecane

【CA登记号】

【分子式】C₁₂H₂₄N₄

【分子量】224.34952

【元素组成】C 64.24% H 10.78% N 24.97%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XV)

A different synthesis started from the previously reported tetraaza cyclopentaacenaphthylene (XV). Treatment of (XV) with a solution of piperazine at pH 6 gave rise to the bicyclic lactam (XVI). Alkylation of (XVI) with bromoacetic acid, followed by basic lactam hydrolysis furnished the tris(carboxymethyl) derivative (X), which was processed as in Scheme 3.

参考文献中间体

合成目标

【1】 Argese, M.; Ripa, G. (Bracco SpA; Dibra SpA); 1,4,7,10-Tetraazabicyclo[8.2.2]tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles. EP 0998476; JP 2002511884; WO 9905145 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	23660	2-Bromoacetic acid	79-08-3	C₂H₃BrO₂	详情	详情
(X)	60030	trisodium 2-[4,10-bis(2-oxido-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetate		C₁₄H₂₃N₄Na₃O₆	详情	详情
(XV)	60034	1,4,7,10-tetraazatricyclo[8.2.2.2~4,7~]hexadecane		C₁₂H₂₄N₄	详情	详情
(XVI)	60035	1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-11-one		C₁₀H₂₀N₄O	详情	详情
(XVII)	60036	2-[7-(2-hydroxy-2-oxoethyl)-11-oxo-1,4,7,10-tetraazabicyclo[8.2.2]tetradec-4-yl]acetic acid		C₁₄H₂₄N₄O₅	详情	详情

Extended Information