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【结 构 式】 
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【分子编号】59308 【品名】 【CA登记号】 |
【 分 子 式 】C15H22N2O 【 分 子 量 】246.35256 【元素组成】C 73.13% H 9% N 11.37% O 6.49% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)An new process for the preparation of the precursor phenylenediamine (V) has been reported. The previously reported 5-chlorobenzimidazole-2-spirocyclohexane (VII) was treated with sodium propoxide to yield the propoxy derivative (VIII). Sodium dithionite reduction of (VIII) gave rise to the target phenylenediamine (V) via intermediate (IX). Then, condensation of diamine (V) with cyanamide and methyl chloroformate produced the target benzimidazole derivative.
| 【1】 Hazelton, J.C.; et al.; 2H-Benzimidazoles (isobenzimidazoles). Part 10. Synthesis of polysubstituted o-phenylenediamines and their conversion into heterocycles, particularly 2-substituted benzimidazoles with known or potential anthelmintic activity. Tetrahedron 1995, 51, 39, 10771. |
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