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【结 构 式】

【分子编号】59307

【品名】 

【CA登记号】

【 分 子 式 】C15H20N2O

【 分 子 量 】244.33668

【元素组成】C 73.74% H 8.25% N 11.47% O 6.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VIII)

An new process for the preparation of the precursor phenylenediamine (V) has been reported. The previously reported 5-chlorobenzimidazole-2-spirocyclohexane (VII) was treated with sodium propoxide to yield the propoxy derivative (VIII). Sodium dithionite reduction of (VIII) gave rise to the target phenylenediamine (V) via intermediate (IX). Then, condensation of diamine (V) with cyanamide and methyl chloroformate produced the target benzimidazole derivative.

1 Hazelton, J.C.; et al.; 2H-Benzimidazoles (isobenzimidazoles). Part 10. Synthesis of polysubstituted o-phenylenediamines and their conversion into heterocycles, particularly 2-substituted benzimidazoles with known or potential anthelmintic activity. Tetrahedron 1995, 51, 39, 10771.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 59305 2-amino-4-propoxyphenylamine; 4-propoxy-1,2-benzenediamine C9H14N2O 详情 详情
(VII) 59306   C12H13ClN2 详情 详情
(VIII) 59307   C15H20N2O 详情 详情
(IX) 59308   C15H22N2O 详情 详情
Extended Information