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【结 构 式】 
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【分子编号】59217 【品名】benzyl ethyl(3-hydroxypropyl)carbamate 【CA登记号】 |
【 分 子 式 】C13H19NO3 【 分 子 量 】237.2988 【元素组成】C 65.8% H 8.07% N 5.9% O 20.23% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Alkylation of ethylamine (II) with 3-chloro-1-propanol (I) in a pressure vessel furnished 3-(ethylamino)-1-propanol (III). After protection of the secondary amine group of (III) upon treatment with benzyl chloroformate, the resultant N-(3-hydroxypropyl)carbamate (IV) was activated as the mesylate ester (V) with methanesulfonyl chloride and triethylamine.
| 【1】 Mignonac, S.; Guy, A.; De Lamer, V. (Sanofi-Synthelabo); Preparation of polyamine(s), substd. on terminal nitrogen atoms. FR 2714052 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 19490 | 3-chloro-1-propanol | 627-30-5 | C3H7ClO | 详情 | 详情 |
| (II) | 10928 | Ethanamine | 75-04-7 | C2H7N | 详情 | 详情 |
| (III) | 59216 | 3-(ethylamino)-1-propanol | C5H13NO | 详情 | 详情 | |
| (IV) | 59217 | benzyl ethyl(3-hydroxypropyl)carbamate | C13H19NO3 | 详情 | 详情 | |
| (V) | 59218 | 3-[[(benzyloxy)carbonyl](ethyl)amino]propyl methanesulfonate | C14H21NO5S | 详情 | 详情 |
Extended Information