• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】59216

【品名】3-(ethylamino)-1-propanol

【CA登记号】

【 分 子 式 】C5H13NO

【 分 子 量 】103.16436

【元素组成】C 58.21% H 12.7% N 13.58% O 15.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Alkylation of ethylamine (II) with 3-chloro-1-propanol (I) in a pressure vessel furnished 3-(ethylamino)-1-propanol (III). After protection of the secondary amine group of (III) upon treatment with benzyl chloroformate, the resultant N-(3-hydroxypropyl)carbamate (IV) was activated as the mesylate ester (V) with methanesulfonyl chloride and triethylamine.

1 Mignonac, S.; Guy, A.; De Lamer, V. (Sanofi-Synthelabo); Preparation of polyamine(s), substd. on terminal nitrogen atoms. FR 2714052 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 19490 3-chloro-1-propanol 627-30-5 C3H7ClO 详情 详情
(II) 10928 Ethanamine 75-04-7 C2H7N 详情 详情
(III) 59216 3-(ethylamino)-1-propanol C5H13NO 详情 详情
(IV) 59217 benzyl ethyl(3-hydroxypropyl)carbamate C13H19NO3 详情 详情
(V) 59218 3-[[(benzyloxy)carbonyl](ethyl)amino]propyl methanesulfonate C14H21NO5S 详情 详情
Extended Information