N-(2-methoxyphenyl)-N,N-dimethylamine; 2-methoxy-N,N-dimethylaniline -Drug Synthesis Database

【结构式】

【分子编号】59068

【品名】N-(2-methoxyphenyl)-N,N-dimethylamine; 2-methoxy-N,N-dimethylaniline

【CA登记号】

【分子式】C₉H₁₃NO

【分子量】151.20836

【元素组成】C 71.49% H 8.67% N 9.26% O 10.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Direct amination of veratrole (I) with lithium dimethylamide produces 2-methoxy-N,N-dimethylaniline (II). The title ammonium salt is then prepared by quaternization of the tertiary amine (II) with allyl bromide (III).

参考文献中间体

合成目标

【1】 Tarver, G.J.; Kaur, J.; Zhang, M.-Q.; Pow, E.; Muir, A.W.; Grove, S.J.A.; Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block. Bioorg Med Chem Lett 2002, 12, 2, 193.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17398	2-methoxyphenyl methyl ether; Veratrole; 1,2-dimethoxybenzene	91-16-7	C₈H₁₀O₂	详情	详情
(II)	59068	N-(2-methoxyphenyl)-N,N-dimethylamine; 2-methoxy-N,N-dimethylaniline		C₉H₁₃NO	详情	详情
(III)	11463	3-Bromo-1-propene; 3-Bromopropene；allyl bromide	106-95-6	C₃H₅Br	详情	详情

Extended Information