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【结 构 式】 
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【药物名称】 【化学名称】N-Allyl-2-methoxy-N,N-dimethylbenzenaminium bromide 【CA登记号】80573-82-6 【 分 子 式 】C12H18BrNO 【 分 子 量 】272.18736 |
【开发单位】Organon (Originator) 【药理作用】Adjuncts to Anesthesia, ANALGESIC AND ANESTHETIC DRUGS, Acetylcholinesterase Inhibitors |
合成路线1
Direct amination of veratrole (I) with lithium dimethylamide produces 2-methoxy-N,N-dimethylaniline (II). The title ammonium salt is then prepared by quaternization of the tertiary amine (II) with allyl bromide (III).
| 【1】 Tarver, G.J.; Kaur, J.; Zhang, M.-Q.; Pow, E.; Muir, A.W.; Grove, S.J.A.; Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block. Bioorg Med Chem Lett 2002, 12, 2, 193. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17398 | 2-methoxyphenyl methyl ether; Veratrole; 1,2-dimethoxybenzene | 91-16-7 | C8H10O2 | 详情 | 详情 |
| (II) | 59068 | N-(2-methoxyphenyl)-N,N-dimethylamine; 2-methoxy-N,N-dimethylaniline | C9H13NO | 详情 | 详情 | |
| (III) | 11463 | 3-Bromo-1-propene; 3-Bromopropene；allyl bromide | 106-95-6 | C3H5Br | 详情 | 详情 |
Extended Information