　 -Drug Synthesis Database

【结构式】

【分子编号】59040

【品名】　

【CA登记号】

【分子式】C₁₂₆H₁₄₃F₁₀N₃₁O₇₉P₁₀

【分子量】3855.404612

【元素组成】C 39.25% H 3.74% F 4.93% N 11.26% O 32.78% P 8.03%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(XI)

Coupling of the deca-nucleotide of 5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP[10]), attached to a solid support, with phosphoramidite (IX) produces the support-bound phosphite adduct (X). After oxidation of (X) to the corresponding phosphate with I2 in aqueous THF, the product is cleaved from the solid support with ammonium hydroxide to furnish (XI).

参考文献中间体

合成目标

【1】 Frank, A.; Karn, H.; Spanig, H. (Abbott GmbH & Co. KG); Production of 1-hydroxyalkyl-5-nitroimidazoles. DE 2359625; FR 2253019; GB 1481349 .
【2】 Frank, A.; Dockner, T.; Karn, H. (Abbott GmbH & Co. KG); Process for the preparation of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole of high purity. EP 0150407 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IX)	59038	16-cyano-13-(diisopropylamino)-5-({4-[({2-{[(E)-(dimethylamino)methylidene]amino}-4-[(4-nitrophenethyl)oxy]-6-pteridinyl}methyl)amino]benzoyl}amino)-4,8-dioxo-12,14-dioxa-3,9-diaza-13-phosphahexadec-1-yl acetate	C₄₅H₆₀N₁₃O₁₀P	详情	详情
(X)	59039		C₁₂₉H₁₄₆F₁₀N₃₂O₇₈P₁₀	详情	详情
(XI)	59040		C₁₂₆H₁₄₃F₁₀N₃₁O₇₉P₁₀	详情	详情

合成路线2

该中间体在本合成路线中的序号：(XI)

The p-nitrophenethyl protecting group of (XI) is finally removed by incubation with a DMF solution of DBU, to provide the title compound.

参考文献中间体

合成目标

【1】 Frank, A.; Karn, H.; Spanig, H. (Abbott GmbH & Co. KG); Production of 1-hydroxyalkyl-5-nitroimidazoles. DE 2359625; FR 2253019; GB 1481349 .
【2】 Frank, A.; Dockner, T.; Karn, H. (Abbott GmbH & Co. KG); Process for the preparation of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole of high purity. EP 0150407 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XI)	59040			C₁₂₆H₁₄₃F₁₀N₃₁O₇₉P₁₀	详情	详情

Extended Information