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【结 构 式】

【分子编号】59039

【品名】 

【CA登记号】

【 分 子 式 】C129H146F10N32O78P10

【 分 子 量 】3892.468772

【元素组成】C 39.81% H 3.78% F 4.88% N 11.51% O 32.06% P 7.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

Coupling of the deca-nucleotide of 5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP[10]), attached to a solid support, with phosphoramidite (IX) produces the support-bound phosphite adduct (X). After oxidation of (X) to the corresponding phosphate with I2 in aqueous THF, the product is cleaved from the solid support with ammonium hydroxide to furnish (XI).

1 Frank, A.; Karn, H.; Spanig, H. (Abbott GmbH & Co. KG); Production of 1-hydroxyalkyl-5-nitroimidazoles. DE 2359625; FR 2253019; GB 1481349 .
2 Frank, A.; Dockner, T.; Karn, H. (Abbott GmbH & Co. KG); Process for the preparation of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole of high purity. EP 0150407 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IX) 59038 16-cyano-13-(diisopropylamino)-5-({4-[({2-{[(E)-(dimethylamino)methylidene]amino}-4-[(4-nitrophenethyl)oxy]-6-pteridinyl}methyl)amino]benzoyl}amino)-4,8-dioxo-12,14-dioxa-3,9-diaza-13-phosphahexadec-1-yl acetate C45H60N13O10P 详情 详情
(X) 59039   C129H146F10N32O78P10 详情 详情
(XI) 59040   C126H143F10N31O79P10 详情 详情
Extended Information