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【结 构 式】 
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【分子编号】58899 【品名】3-furylmethanamine; 3-furylmethylamine 【CA登记号】 |
【 分 子 式 】C5H7NO 【 分 子 量 】97.11672 【元素组成】C 61.84% H 7.27% N 14.42% O 16.47% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Arachidonic acid (I) is converted to the corresponding acid chloride (II) by treatment with oxalyl chloride and DMF. Subsequent condensation of acid chloride (II) with 3-furylmethylamine (III) leads to the desired arachidonic acid amide.
| 【1】 Fernández-Ruiz, J.; Viso, A.; Ortega-Gutiérrez, S.; Ramos, J.A.; González, S.; López-Rodríguez, M.L.; Lastres-Becker, I.; Design, synthesis and biological evaluation of novel arachidonic acis derivatives as highly potent and selective endocannabinoid transporter inhibitors. J Med Chem 2001, 44, 26, 4505. |
| 【2】 Lopez Rodriguez, M.L.; Viso Beronda, A.; Ortega Gutierrez, S.; Latres Becker, I.; Gonzalez Rodriguez de Castro, S.; Fernandez Ruiz, J.J.; Ramos Atance, J.A. (Universidad Complutense de Madrid); Novel araquidonic acid derivs. with affinity toward the anandamide transporter. WO 0212167 . |
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