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【结 构 式】 
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【药物名称】UCM-707 【化学名称】N-(Furan-3-ylmethyl)-5(Z),8(Z),11(Z),14(Z)-icosatetraenamide 【CA登记号】390824-20-1 【 分 子 式 】C25H37NO2 【 分 子 量 】383.57914 |
【开发单位】Universidad Complutense de Madrid (Originator) 【药理作用】Extrapyramidal Disorders, Treatment of, Huntington's Disease, Treatment of, Immunologic Neuromuscular Disorders, Treatment of, Multiple Sclerosis, Agents for, NEUROLOGIC DRUGS, ONCOLYTIC DRUGS, Drugs Acting on Cannabinoid Receptors |
合成路线1
Arachidonic acid (I) is converted to the corresponding acid chloride (II) by treatment with oxalyl chloride and DMF. Subsequent condensation of acid chloride (II) with 3-furylmethylamine (III) leads to the desired arachidonic acid amide.
| 【1】 Fernández-Ruiz, J.; Viso, A.; Ortega-Gutiérrez, S.; Ramos, J.A.; González, S.; López-Rodríguez, M.L.; Lastres-Becker, I.; Design, synthesis and biological evaluation of novel arachidonic acis derivatives as highly potent and selective endocannabinoid transporter inhibitors. J Med Chem 2001, 44, 26, 4505. |
| 【2】 Lopez Rodriguez, M.L.; Viso Beronda, A.; Ortega Gutierrez, S.; Latres Becker, I.; Gonzalez Rodriguez de Castro, S.; Fernandez Ruiz, J.J.; Ramos Atance, J.A. (Universidad Complutense de Madrid); Novel araquidonic acid derivs. with affinity toward the anandamide transporter. WO 0212167 . |
Extended Information