合成路线1

Methyl 2,6-difluorobenzoate (I) was converted to the hydroxamic acid (II) upon treatment with hydroxylamine and KOH. Cyclization of the fluorobenzohydroxamic acid (II) using KOH in boiling butanol produced the 3-hydroxybenzisoxazole (III), which was subjected to Mitsunobu coupling with N-Boc-ethanolamine (IV) to furnish the N-Boc-aminoethyl ether (V). Metalation of (V) with butyllithium at -70 C, followed by quenching with iodomethane gave rise to two regioisomeric methylbenzisoxazoles (VI) and (VII), which were separated by column chromatography. The target 7-methyl benzisoxazole (VII) was then deprotected under acidic conditions to yield the title aminoethoxy derivative.