【结 构 式】 |
【分子编号】58613 【品名】3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzaldehyde 【CA登记号】 |
【 分 子 式 】C16H15IO3 【 分 子 量 】382.19777 【元素组成】C 50.28% H 3.96% I 33.2% O 12.56% |
合成路线1
该中间体在本合成路线中的序号:(XIII)Synthesis of the iodo-L-phenylalanine intermediate (XVII): The condensation of catechol derivative (IX) with methyl orthoformate by means of BuLi and CSA in methanol gives the benzaldehyde dimethyl acetal (X), which is iodinated with I2 and BuLi in ethyl ether to yield the iodobenzaldehyde acetal (XI). The hydrolysis of the acetal group of (XI) by means of HCl in THF affords the 3-hydroxy benzaldehyde derivative (XII), which is treated with benzyl bromide and K2CO3 in refluxing acetonitrile to provide the benzyl protected benzaldehyde derivative (XIII). The Horner-Emmons condensation of aldehyde (XIII) with phosphonate (XIV) by means of TMG in dichloromethane gives the dehydrophenylalanine derivative (XV), which is submitted to an asymmetric hydrogenation with H2 over a chiral Rh catalyst in hot ethyl acetate to yield the L-enantiomer (XVI). Finally, the ester group of (XVI) is hydrolyzed with LiOH in methanol/water to afford the target iodo-L-phenylalanine intermediate (XVII).
【1】 Abe, M.; Yanagisawa, A.; Tohma, S.; Kan, T.; Fukuyama, T.; Endo, A.; Total synthesis of ecteinascidin 743. J Am Chem Soc 2002, 124, 23, 6552. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(IX) | 58609 | 4-bromo-2-(methoxymethoxy)-6-methylphenyl methyl ether; 5-bromo-2-methoxy-1-(methoxymethoxy)-3-methylbenzene | C10H13BrO3 | 详情 | 详情 | |
(X) | 58610 | 5-(dimethoxymethyl)-2-methoxy-1-(methoxymethoxy)-3-methylbenzene; 4-(dimethoxymethyl)-2-(methoxymethoxy)-6-methylphenyl methyl ether | C13H20O5 | 详情 | 详情 | |
(XI) | 58611 | 1-(dimethoxymethyl)-2-iodo-4-methoxy-3-(methoxymethoxy)-5-methylbenzene; 4-(dimethoxymethyl)-3-iodo-2-(methoxymethoxy)-6-methylphenyl methyl ether | C13H19IO5 | 详情 | 详情 | |
(XII) | 58612 | 3-hydroxy-2-iodo-4-methoxy-5-methylbenzaldehyde | C9H9IO3 | 详情 | 详情 | |
(XIII) | 58613 | 3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzaldehyde | C16H15IO3 | 详情 | 详情 | |
(XIV) | 34562 | methyl 2-[(tert-butoxycarbonyl)amino]-2-(dimethoxyphosphoryl)acetate | C10H20NO7P | 详情 | 详情 | |
(XV) | 58614 | methyl (Z)-3-[3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl]-2-[(tert-butoxycarbonyl)amino]-2-propenoate | C24H28INO6 | 详情 | 详情 | |
(XVI) | 58615 | methyl (2S)-3-[3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl]-2-[(tert-butoxycarbonyl)amino]propanoate | C24H30INO6 | 详情 | 详情 | |
(XVII) | 58616 | (2S)-3-[3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid | C23H28INO6 | 详情 | 详情 |