【结 构 式】 |
【分子编号】58509 【品名】4-(1,3-benzothiazol-2-yl)aniline; 4-(1,3-benzothiazol-2-yl)phenylamine 【CA登记号】 |
【 分 子 式 】C13H10N2S 【 分 子 量 】226.30188 【元素组成】C 69% H 4.45% N 12.38% S 14.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Condensation of 2-aminothiophenol (I) with 4-nitrobenzoyl chloride (II) produces the benzothiazole (III). Reduction of the nitro group of (III) by means of SnCl2 in refluxing EtOH yields aniline (IV). Then, alkylation of (IV) with 11C-labeled iodomethane gives rise to the target 11C-methylated aniline.
【1】 Mathis, C.A.; et al.; A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett 2002, 12, 3, 295. |
【2】 Wang, Y.; Klunk, W.E.; Mathis, C.A. Jr. (University of Pittsburgh); Thioflavin derivs. for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition. WO 0216333 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 25182 | 2-aminobenzenethiol | 137-07-5 | C6H7NS | 详情 | 详情 |
(II) | 18941 | p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride | 122-04-3 | C7H4ClNO3 | 详情 | 详情 |
(III) | 58508 | 2-(4-nitrophenyl)-1,3-benzothiazole | C13H8N2O2S | 详情 | 详情 | |
(IV) | 58509 | 4-(1,3-benzothiazol-2-yl)aniline; 4-(1,3-benzothiazol-2-yl)phenylamine | C13H10N2S | 详情 | 详情 |
Extended Information