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【结 构 式】

【分子编号】58457

【品名】N,N-dimethyl-N'-(4-piperidinyl)sulfamide

【CA登记号】

【 分 子 式 】C7H17N3O2S

【 分 子 量 】207.297

【元素组成】C 40.56% H 8.27% N 20.27% O 15.44% S 15.47%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

4-Amino-1-benzylpiperidine (VIII) is condensed with dimethylsulfamoyl chloride to give the sulfamide (IX). Subsequent benzyl group hydrogenolysis in (IX) over Pd/C provides the piperidine (X). Finally, alkylation of piperidine (X) with chloride (VII) yields the title compound.

1 Kaneko, T.; et al.; Inhibitors of adhesion molecules expression: The synthesis and pharmacological properties of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives. Chem Pharm Bull 2002, 50, 7, 922.
2 Kaneko, T.; Clark, R.; Ohi, N.; Ozaki, F.; Kawahara, T.; Kamada, A.; Okano, K.; Yokohama, H.; Muramoto, K.; Arai, T.; Ohkuro, M.; Takenaka, O.; Sonoda, J. (Eisai Co., Ltd.); Benzopiperidine derivs.. EP 0934941; WO 9806720 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VII) 58455 8-(chloromethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine C11H8ClN3S 详情 详情
(VIII) 34808 1-Benzyl-4-piperidinylamine; 1-Benzyl-4-piperidinamine; 4-Amino-1-benzylpiperidine 50541-93-0 C12H18N2 详情 详情
(IX) 58456 N'-(1-benzyl-4-piperidinyl)-N,N-dimethylsulfamide C14H23N3O2S 详情 详情
(X) 58457 N,N-dimethyl-N'-(4-piperidinyl)sulfamide C7H17N3O2S 详情 详情
Extended Information