N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-methyl-1H-indole-2-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】58346

【品名】N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-methyl-1H-indole-2-carboxamide

【CA登记号】

【分子式】C₂₃H₂₇BN₂O₄

【分子量】406.28946

【元素组成】C 67.99% H 6.7% B 2.66% N 6.89% O 15.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVI)

In a related procedure, the pyrazolopyrimidinyl iodide (IX) is coupled to the (indolecarboxamido)phenyl boronate (XVI) under Suzuki reaction conditions, leading directly to the title compound.

参考文献中间体

合成目标

【1】 Ferraris, D.; et al.; Design, synthesis and SAR of PARP-1 inhibitors. Drugs Fut 2002, 27, Suppl. A.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IX)	57054	3-iodo-1-[4-(4-methyl-1-piperazinyl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-iodo-1-[4-(4-methyl-1-piperazinyl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine		C₁₆H₂₄IN₇	详情	详情
(XVI)	58346	N-[2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-methyl-1H-indole-2-carboxamide		C₂₃H₂₇BN₂O₄	详情	详情

Extended Information