[8-cyclopentyl-3-(3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-2,6-dioxo-1-propyl-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl pivalate -Drug Synthesis Database

【结构式】

【分子编号】58261

【品名】[8-cyclopentyl-3-(3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-2,6-dioxo-1-propyl-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl pivalate

【CA登记号】

【分子式】C₂₉H₄₀N₄O₇S

【分子量】588.72536

【元素组成】C 59.16% H 6.85% N 9.52% O 19.02% S 5.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 8-cyclopentyl-3-(3-hydroxypropyl)-1-propylxanthine (I) with Ts-Cl and TEA gives the corresponding tosylate (II), which is then radiolabeled by means of 18FK and Kryptofix to provide the target radiolabeled compound.

参考文献中间体

合成目标

【1】 Morikawa, K.; Koizumi, M.; Endo, K.; Yono, T.; Mitusui, H.; Akamatsu, K.; Honda, H.; Synthesis and antitumor activity of platinum complexes (I). 106th Annu Meet Pharm Soc Jpn (Chiba) 1986, Abstr. 4E 10-2.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	58260	[8-cyclopentyl-3-(3-hydroxypropyl)-2,6-dioxo-1-propyl-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl pivalate		C₂₂H₃₄N₄O₅	详情	详情
(II)	58261	[8-cyclopentyl-3-(3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-2,6-dioxo-1-propyl-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl pivalate		C₂₉H₄₀N₄O₇S	详情	详情

Extended Information