　 -Drug Synthesis Database

【结构式】

【分子编号】58166

【品名】　

【CA登记号】

【分子式】C₁₅₇H₂₃₀O₇₂

【分子量】3269.51

【元素组成】C 57.68% H 7.09% O 35.23%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(XXXVI)

The nonasaccharide imidate (XXVI) is coupled to the tetrasaccharide acceptor (XXXIV) to provide adduct (XXXV). Subsequent deprotection of the levulinate ester of (XXXV) to afford (XXXVI) is effected by treatment with hydrazine acetate.

参考文献中间体

合成目标

【1】 Petitou, M.; Herbert, J.-M.; Duchaussoy, P.; Basten, J.; Dreef-Tromp, C.; Driguez, P.-A.; Van Boeckel, C. (Akzo Nobel N.V.; Sanofi-Synthélabo); Synthetic polysaccharides, their method of production and pharmaceutical compsns. containing same. EP 1049721; FR 2773804; US 6528497; WO 9936443 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XXVI)	58156		C₉₅H₁₅₄Cl₃NO₅₀	详情	详情
(XXXIV)	58164	benzyl (2R,3S,4S,5R,6R)-6-{[(2R,3R,4R,5R,6S)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(benzyloxy)-6-({(2R,3S,4R,5R,6R)-6-({(2R,3S,4R,5R,6S)-5-(benzyloxy)-2-[(benzyloxy)methyl]-4,6-dimethoxytetrahydro-2H-pyran-3-yl}oxy)-2-[(benzyloxy)carbonyl]-4,5-dimethoxytetrahydro-2H-pyran-3-yl}oxy)tetrahydro-2H-pyran-3-yl]oxy}-3-hydroxy-4,5-dimethoxytetrahydro-2H-pyran-2-carboxylate	C₆₉H₈₄O₂₅	详情	详情
(XXXV)	58165		C₁₆₂H₂₃₆O₇₄	详情	详情
(XXXVI)	58166		C₁₅₇H₂₃₀O₇₂	详情	详情

合成路线2

该中间体在本合成路线中的序号：(XXXVI)

Coupling of polysaccharide (XXXVI) with the thioglycoside (V) using N-iodosuccinimide and trifluromethanesulfonic acid provides (XXXVII). The benzyl ether and ester groups of (XXXVII) are then removed by hydrogenolysis in the presence of Pd/C to produce (XXXVIII).

参考文献中间体

合成目标

【1】 Petitou, M.; Herbert, J.-M.; Duchaussoy, P.; Basten, J.; Dreef-Tromp, C.; Driguez, P.-A.; Van Boeckel, C. (Akzo Nobel N.V.; Sanofi-Synthélabo); Synthetic polysaccharides, their method of production and pharmaceutical compsns. containing same. EP 1049721; FR 2773804; US 6528497; WO 9936443 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(V)	58136	(2S,3R,4S,5S,6R)-3-(benzoyloxy)-6-[(benzoyloxy)methyl]-5-{[(2R,3R,4S,5R,6R)-3,4-bis(benzoyloxy)-6-[(benzoyloxy)methyl]-5-({(2R,3R,4S,5R,6R)-3,4,5-tris(benzoyloxy)-6-[(benzoyloxy)methyl]tetrahydro-2H-pyran-2-yl}oxy)tetrahydro-2H-pyran-2-yl]oxy}-2-(ethylsulfanyl)tetrahydro-2H-pyran-4-yl benzoate	C₉₀H₇₆O₂₅S	详情	详情
(XXXVI)	58166		C₁₅₇H₂₃₀O₇₂	详情	详情
(XXXVII)	58167		C₂₄₅H₃₀₀O₉₇	详情	详情
(XXXVIII)	58168		C₁₉₇H₂₆₃AcO₉₅	详情	详情

Extended Information