【结 构 式】 |
【分子编号】58156 【品名】 【CA登记号】 |
【 分 子 式 】C95H154Cl3NO50 【 分 子 量 】2216.6026 【元素组成】C 51.48% H 7% Cl 4.8% N 0.63% O 36.09% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(XXVI)The glycosidic acetate group of (XXIV) is selectively hydrolyzed to (XXV) by means of morpholine in toluene. Activation of (XXV) by means of trichloroacetonitrile produces imidate (XXVI).
【1】 Petitou, M.; Herbert, J.-M.; Duchaussoy, P.; Basten, J.; Dreef-Tromp, C.; Driguez, P.-A.; Van Boeckel, C. (Akzo Nobel N.V.; Sanofi-Synthélabo); Synthetic polysaccharides, their method of production and pharmaceutical compsns. containing same. EP 1049721; FR 2773804; US 6528497; WO 9936443 . |
合成路线2
该中间体在本合成路线中的序号:(XXVI)The nonasaccharide imidate (XXVI) is coupled to the tetrasaccharide acceptor (XXXIV) to provide adduct (XXXV). Subsequent deprotection of the levulinate ester of (XXXV) to afford (XXXVI) is effected by treatment with hydrazine acetate.
【1】 Petitou, M.; Herbert, J.-M.; Duchaussoy, P.; Basten, J.; Dreef-Tromp, C.; Driguez, P.-A.; Van Boeckel, C. (Akzo Nobel N.V.; Sanofi-Synthélabo); Synthetic polysaccharides, their method of production and pharmaceutical compsns. containing same. EP 1049721; FR 2773804; US 6528497; WO 9936443 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XXVI) | 58156 | C95H154Cl3NO50 | 详情 | 详情 | ||
(XXXIV) | 58164 | benzyl (2R,3S,4S,5R,6R)-6-{[(2R,3R,4R,5R,6S)-4-(acetyloxy)-2-[(acetyloxy)methyl]-5-(benzyloxy)-6-({(2R,3S,4R,5R,6R)-6-({(2R,3S,4R,5R,6S)-5-(benzyloxy)-2-[(benzyloxy)methyl]-4,6-dimethoxytetrahydro-2H-pyran-3-yl}oxy)-2-[(benzyloxy)carbonyl]-4,5-dimethoxytetrahydro-2H-pyran-3-yl}oxy)tetrahydro-2H-pyran-3-yl]oxy}-3-hydroxy-4,5-dimethoxytetrahydro-2H-pyran-2-carboxylate | C69H84O25 | 详情 | 详情 | |
(XXXV) | 58165 | C162H236O74 | 详情 | 详情 | ||
(XXXVI) | 58166 | C157H230O72 | 详情 | 详情 |
Extended Information