2-[(3,4-dimethoxyphenethyl)(2-hydroxyethyl)amino]-1-ethanol -Drug Synthesis Database

【结构式】

【分子编号】57495

【品名】2-[(3,4-dimethoxyphenethyl)(2-hydroxyethyl)amino]-1-ethanol

【CA登记号】

【分子式】C₁₄H₂₃NO₄

【分子量】269.34096

【元素组成】C 62.43% H 8.61% N 5.2% O 23.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The alkylation of 2-(3,4-dimethoxyphenyl)ethylamine (I) with 2-bromoethanol (II) provides the bis(hydroxyethyl) amine (III). Subsequent chlorination of diol (III) with SOCl2 affords the corresponding bis(chloroethyl) amine (IV). This is finally cyclized with 3-phenylpropylamine (V) to furnish the title piperazine derivative, which is isolated as the dihydrochloride salt.

参考文献中间体

合成目标

【1】 Kawashima, Y.; Matsumoto, J.; Matsuno, K.; Senda, T.; Hirano, K. (Santen Pharmaceutical Co., Ltd.); Novel 1,4-di(phenylalkyl)piperazine deriv.. EP 0711763; JP 1995089949; US 5736546; WO 9504050 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10098	2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine	120-20-7	C₁₀H₁₅NO₂	详情	详情
(II)	10059	Ethylene bromohydrin; 2-Bromo-1-ethanol	540-51-2	C₂H₅BrO	详情	详情
(III)	57495	2-[(3,4-dimethoxyphenethyl)(2-hydroxyethyl)amino]-1-ethanol		C₁₄H₂₃NO₄	详情	详情
(IV)	57496	N,N-bis(2-chloroethyl)-N-(3,4-dimethoxyphenethyl)amine; 2-chloro-N-(2-chloroethyl)-N-(3,4-dimethoxyphenethyl)-1-ethanamine		C₁₄H₂₁Cl₂NO₂	详情	详情
(V)	18791	3-phenylpropylamine; 3-phenyl-1-propanamine	2038-57-5	C₉H₁₃N	详情	详情

Extended Information