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【结 构 式】 
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【药物名称】Msc1, SA-4503 【化学名称】1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride 【CA登记号】165377-44-6 【 分 子 式 】C23H34Cl2N2O2 【 分 子 量 】441.44563 |
【开发单位】Santen (Originator), M's Science (Licensee) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS, TREATMENT OF POISONING, DRUG ABUSE & DEPENDENCY, Treatment of Substance Dependency, Acetylcholine Release Enhancers, sigma Receptor Agonists |
合成路线1
The alkylation of 2-(3,4-dimethoxyphenyl)ethylamine (I) with 2-bromoethanol (II) provides the bis(hydroxyethyl) amine (III). Subsequent chlorination of diol (III) with SOCl2 affords the corresponding bis(chloroethyl) amine (IV). This is finally cyclized with 3-phenylpropylamine (V) to furnish the title piperazine derivative, which is isolated as the dihydrochloride salt.
| 【1】 Kawashima, Y.; Matsumoto, J.; Matsuno, K.; Senda, T.; Hirano, K. (Santen Pharmaceutical Co., Ltd.); Novel 1,4-di(phenylalkyl)piperazine deriv.. EP 0711763; JP 1995089949; US 5736546; WO 9504050 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10098 | 2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine | 120-20-7 | C10H15NO2 | 详情 | 详情 |
| (II) | 10059 | Ethylene bromohydrin; 2-Bromo-1-ethanol | 540-51-2 | C2H5BrO | 详情 | 详情 |
| (III) | 57495 | 2-[(3,4-dimethoxyphenethyl)(2-hydroxyethyl)amino]-1-ethanol | C14H23NO4 | 详情 | 详情 | |
| (IV) | 57496 | N,N-bis(2-chloroethyl)-N-(3,4-dimethoxyphenethyl)amine; 2-chloro-N-(2-chloroethyl)-N-(3,4-dimethoxyphenethyl)-1-ethanamine | C14H21Cl2NO2 | 详情 | 详情 | |
| (V) | 18791 | 3-phenylpropylamine; 3-phenyl-1-propanamine | 2038-57-5 | C9H13N | 详情 | 详情 |