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【结 构 式】 
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【分子编号】57383 【品名】Boc-1-aminocyclopropane-1-carboxylic acid; Boc-aminocyclopropanecarboxylic acid; Boc-L-alpha-aminocyclopropanecarboxylic acid 【CA登记号】88950-64-5 |
【 分 子 式 】C9H15NO4 【 分 子 量 】201.22244 【元素组成】C 53.72% H 7.51% N 6.96% O 31.8% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)1-Amino-1-cyclopropanecarboxylic acid (X) is protected as the N-Boc derivative (XI) employing Boc2O and NaOH in aqueous dioxane. Carbonyldiimidazole-mediated coupling of the Boc-aminoacid (XI) with butanesulfonamide (XII) produces the N-acyl sulfonamide (XIII). The N-Boc group of (XIII) is then cleaved under acidic conditions to give amine (XIV). This is finally coupled with acid (IX) in the presence of EDC and HOAt to furnish the corresponding amide.
| 【1】 Ksander, G.M.; Kukkola, P.J.; Robinson, L.A. (Novartis AG); N-aroylamino acid amides as endothelin inhibitors. EP 0821670; JP 1999505522; WO 9633170 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 57379 | (2R)-2-[(3,5-dimethylbenzoyl)(methyl)amino]-3-[4-(1H-pyrrol-1-yl)phenyl]propanoic acid | C23H24N2O3 | 详情 | 详情 | |
| (X) | 57382 | 1-Amino-1-cyclopropanecarboxylic acid; 1-Aminocyclopropane-1-carboxylic acid; 1-aminocyclopropane carboxylic acid; Carboxycyclopropylamine | 22059-21-8 | C4H7NO2 | 详情 | 详情 |
| (XI) | 57383 | Boc-1-aminocyclopropane-1-carboxylic acid; Boc-aminocyclopropanecarboxylic acid; Boc-L-alpha-aminocyclopropanecarboxylic acid | 88950-64-5 | C9H15NO4 | 详情 | 详情 |
| (XII) | 26780 | 1-butanesulfonamide | C4H11NO2S | 详情 | 详情 | |
| (XIII) | 57384 | tert-butyl 1-{[(butylsulfonyl)amino]carbonyl}cyclopropylcarbamate | C13H24N2O5S | 详情 | 详情 | |
| (XIV) | 57385 | N-[(1-aminocyclopropyl)carbonyl]-1-butanesulfonamide | C8H16N2O3S | 详情 | 详情 |
Extended Information