1-butanesulfonamide -Drug Synthesis Database

【结构式】

【分子编号】26780

【品名】1-butanesulfonamide

【CA登记号】

【分子式】C₄H₁₁NO₂S

【分子量】137.20288

【元素组成】C 35.02% H 8.08% N 10.21% O 23.32% S 23.37%

与该中间体有关的原料药合成路线共 3 条

合成路线1 合成路线2 合成路线3

合成路线1

该中间体在本合成路线中的序号：(XIII)

1-Butanesulfonyl chloride (XII) was reacted with ammonia in acetonitrile, and the resulting sulfonamide (XIII) was then converted to the N-trimethylsilyl derivative (XIV). This was coupled with acid fluoride (XVII), (obtained from Boc-valine (XV) and cyanuric fluoride (XVI)), to provide Boc-valinesulfonamide (XVIII). The Boc group of (XVIII) was then removed by acid treatment to give (XIX). Finally, coupling of this chiral intermediate with the previously obtained racemic acid (XI) furnished the title compound as a 7:3 mixture of diastereoisomers.

参考文献中间体

合成目标

【1】 Sakaki, J.; Murata, T.; Yuumoto, Y.; Nakamura, I.; Frueh, T.; Pitterna, T.; Iwasaki, G.; Oda, K.; Yamamura, T.; Hayakawa, K.; Discovery of IRL 3461: A novel and potent endothelin antagonist with balanced ETA/ETB affinity. Bioorg Med Chem Lett 1998, 8, 16, 2241.
【2】 Fruh, T.; Pitterna, T.; Murata, T.; Svensson, L.D.; Yuumoto, Y.; Sakaki, J. (Novartis Japan KK); Antagonists of endothelin receptors. EP 0753004; JP 1997510720; US 5703106; WO 9526360 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XI)	26778	N-(3,5-dimethylbenzoyl)-4-(5-isoxazolyl)-N-methylphenylalanine		C₂₂H₂₂N₂O₄	详情	详情
(XII)	26779	1-butanesulfonyl chloride	2386-60-9	C₄H₉ClO₂S	详情	详情
(XIII)	26780	1-butanesulfonamide		C₄H₁₁NO₂S	详情	详情
(XIV)	26781	N-(trimethylsilyl)-1-butanesulfonamide		C₇H₁₉NO₂SSi	详情	详情
(XV)	19733	(2S)-2-[(tert-butoxycarbonyl)amino]-3-methylbutyric acid		C₁₀H₁₉NO₄	详情	详情
(XVI)	26782	Cyanuric fluoride; 2,4,6-trifluoro-1,3,5-triazine	675-14-9	C₃F₃N₃	详情	详情
(XVII)	26783	tert-butyl (1S)-1-(fluorocarbonyl)-2-methylpropylcarbamate		C₁₀H₁₈FNO₃	详情	详情
(XVIII)	26784	tert-butyl (1S)-1-[[(butylsulfonyl)amino]carbonyl]-2-methylpropylcarbamate		C₁₄H₂₈N₂O₅S	详情	详情
(XIX)	26785	N-[(2S)-2-amino-3-methylbutanoyl]-1-butanesulfonamide		C₉H₂₀N₂O₃S	详情	详情

合成路线2

该中间体在本合成路线中的序号：(XII)

1-Amino-1-cyclopropanecarboxylic acid (X) is protected as the N-Boc derivative (XI) employing Boc2O and NaOH in aqueous dioxane. Carbonyldiimidazole-mediated coupling of the Boc-aminoacid (XI) with butanesulfonamide (XII) produces the N-acyl sulfonamide (XIII). The N-Boc group of (XIII) is then cleaved under acidic conditions to give amine (XIV). This is finally coupled with acid (IX) in the presence of EDC and HOAt to furnish the corresponding amide.

参考文献中间体

合成目标

【1】 Ksander, G.M.; Kukkola, P.J.; Robinson, L.A. (Novartis AG); N-aroylamino acid amides as endothelin inhibitors. EP 0821670; JP 1999505522; WO 9633170 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IX)	57379	(2R)-2-[(3,5-dimethylbenzoyl)(methyl)amino]-3-[4-(1H-pyrrol-1-yl)phenyl]propanoic acid		C₂₃H₂₄N₂O₃	详情	详情
(X)	57382	1-Amino-1-cyclopropanecarboxylic acid; 1-Aminocyclopropane-1-carboxylic acid; 1-aminocyclopropane carboxylic acid; Carboxycyclopropylamine	22059-21-8	C₄H₇NO₂	详情	详情
(XI)	57383	Boc-1-aminocyclopropane-1-carboxylic acid; Boc-aminocyclopropanecarboxylic acid; Boc-L-alpha-aminocyclopropanecarboxylic acid	88950-64-5	C₉H₁₅NO₄	详情	详情
(XII)	26780	1-butanesulfonamide		C₄H₁₁NO₂S	详情	详情
(XIII)	57384	tert-butyl 1-{[(butylsulfonyl)amino]carbonyl}cyclopropylcarbamate		C₁₃H₂₄N₂O₅S	详情	详情
(XIV)	57385	N-[(1-aminocyclopropyl)carbonyl]-1-butanesulfonamide		C₈H₁₆N₂O₃S	详情	详情

合成路线3

该中间体在本合成路线中的序号：(XIII)

1-Butanesulfonyl chloride (XII) was reacted with ammonia in acetonitrile, and the resulting sulfonamide (XIII) was then converted to the N-trimethylsilyl derivative (XIV). This compound was coupled with acid fluoride (XVII), (obtained from Boc-valine (XV) and cyanuric fluoride (XVI)), to provide Boc-valinesulfonamide (XVIII). The Boc group of (XVIII) was then removed by acid treatment to give (XIX). Coupling of this chiral intermediate (XIX) with racemic acid (XI) in a biphasic solvent system, with partial isomerization of acid (XI), furnished the amide (XX) as a 12:1 diastereomeric mixture. The major D,L diastereoisomer was then isolated either by preparative HPLC or by recrystallization from isopropanol.

参考文献中间体

合成目标

【1】 Sakaki, J.; Murata, T.; Yuumoto, Y.; Nakamura, I.; Hayakawa, K.; Stereoselective synthesis of a novel and bifunctional endothelin antagonist, IRL 3630. Bioorg Med Chem Lett 1998, 8, 16, 2247.
【2】 Sakaki, J.; Murata, T.; Yuumoto, Y.; Nakamura, I.; Okada, T. (Novartis Japan KK); Antagonists of endothelin receptors. JP 1999512702; WO 9711960 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XI)	26778	N-(3,5-dimethylbenzoyl)-4-(5-isoxazolyl)-N-methylphenylalanine		C₂₂H₂₂N₂O₄	详情	详情
(XII)	26779	1-butanesulfonyl chloride	2386-60-9	C₄H₉ClO₂S	详情	详情
(XIII)	26780	1-butanesulfonamide		C₄H₁₁NO₂S	详情	详情
(XIV)	26781	N-(trimethylsilyl)-1-butanesulfonamide		C₇H₁₉NO₂SSi	详情	详情
(XV)	19733	(2S)-2-[(tert-butoxycarbonyl)amino]-3-methylbutyric acid		C₁₀H₁₉NO₄	详情	详情
(XVI)	26782	Cyanuric fluoride; 2,4,6-trifluoro-1,3,5-triazine	675-14-9	C₃F₃N₃	详情	详情
(XVII)	26783	tert-butyl (1S)-1-(fluorocarbonyl)-2-methylpropylcarbamate		C₁₀H₁₈FNO₃	详情	详情
(XVIII)	26784	tert-butyl (1S)-1-[[(butylsulfonyl)amino]carbonyl]-2-methylpropylcarbamate		C₁₄H₂₈N₂O₅S	详情	详情
(XIX)	26785	N-[(2S)-2-amino-3-methylbutanoyl]-1-butanesulfonamide		C₉H₂₀N₂O₃S	详情	详情
(XX)	26786	N-[2-[((1S)-1-[[(butylsulfonyl)amino]carbonyl]-2-methylpropyl)amino]-1-[4-(5-isoxazolyl)benzyl]-2-oxoethyl]-N,3,5-trimethylbenzamide		C₃₁H₄₀N₄O₆S	详情	详情

Extended Information